PMID- 10648732 OWN - NLM STAT- MEDLINE DCOM- 20000602 LR - 20191023 IS - 1529-2401 (Electronic) IS - 0270-6474 (Print) IS - 0270-6474 (Linking) VI - 20 IP - 3 DP - 2000 Feb 1 TI - Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats. PG - RC57 AB - Segregation and stabilization of thalamocortical afferents to eye-specific patches, so-called "ocular dominance (OD) columns," in visual cortex are hypothesized to be based on activity-dependent competition for trophic factors such as brain-derived neurotrophic factor (BDNF) between afferents representing the two eyes during the critical period of postnatal development. To test this hypothesis we observed effects of an intracortical infusion of BDNF on OD columns in monocularly deprived kittens and also compared effects between normal kittens and adult cats. BDNF had a hypertrophic action on afferents irrespective of visual inputs so that it desegregated OD columns in the visual cortex of deprived and normal kittens, but this action was not seen in the adults, substantiating its hypothesized trophic role in plasticity of OD columns in the developing visual cortex. FAU - Hata, Y AU - Hata Y AD - Department of Neurophysiology, Biomedical Research Center, Osaka University Medical School, 2-2 Yamadaoka, Suita,Osaka 565-0871, Japan. hata@nphys.med.osaka-u.ac.jp FAU - Ohshima, M AU - Ohshima M FAU - Ichisaka, S AU - Ichisaka S FAU - Wakita, M AU - Wakita M FAU - Fukuda, M AU - Fukuda M FAU - Tsumoto, T AU - Tsumoto T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Neurosci JT - The Journal of neuroscience : the official journal of the Society for Neuroscience JID - 8102140 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Autoradiography MH - Brain-Derived Neurotrophic Factor/pharmacology/*physiology MH - Cats MH - Immunohistochemistry MH - Neuronal Plasticity MH - Thalamus/physiology MH - Vision, Binocular/physiology MH - Vision, Monocular/*physiology MH - Visual Cortex/anatomy & histology/growth & development/*physiology MH - Visual Pathways/*physiology PMC - PMC6774162 EDAT- 2000/01/29 00:00 MHDA- 2000/06/10 00:00 PMCR- 2000/08/01 CRDT- 2000/01/29 00:00 PHST- 2000/01/29 00:00 [pubmed] PHST- 2000/06/10 00:00 [medline] PHST- 2000/01/29 00:00 [entrez] PHST- 2000/08/01 00:00 [pmc-release] AID - 3880 [pii] AID - 10.1523/JNEUROSCI.20-03-j0002.2000 [doi] PST - ppublish SO - J Neurosci. 2000 Feb 1;20(3):RC57. doi: 10.1523/JNEUROSCI.20-03-j0002.2000.