PMID- 10648888
OWN - NLM
STAT- MEDLINE
DCOM- 20000307
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 75
IP  - 1
DP  - 2000 Jan 10
TI  - Cell death in regenerating populations of neurons in BDNF mutant mice.
PG  - 61-9
AB  - There are two populations of neurons which are continually renewed in the adult, 
      the dentate gyrus granule neurons and the olfactory bulb granule and 
      periglomerular neurons. In the dentate gyrus, a secondary proliferative zone 
      termed the subgranular zone is established along the interface between the 
      dentate gyrus and the hilus where granule cells are born throughout life. 
      Olfactory bulb neurons are generated in the anterior subventricular zone of the 
      lateral ventricle and migrate via the rostral migratory stream to the olfactory 
      bulb. We examined animals lacking brain-derived neurotrophic factor (BDNF) in 
      order to establish whether this neurotrophin could be involved in the generation 
      and/or survival of these neurons in vivo. We find that cells in nestin-positive 
      regions of both the subgranular layer of the dentate gyrus and the subventricular 
      zone of the olfactory bulb undergo apoptosis starting 2 weeks after birth in the 
      absence of BDNF. However, increased apoptosis was not limited to precursors, as 
      apoptotic cells were also found in the granule cell layer of the dentate gyrus 
      and in the granule and periglomerular layers of the olfactory bulb. The excessive 
      cell death was limited to these populations of neurons as no excessive cell death 
      was detected in other forebrain areas. We conclude that BDNF is essential for the 
      survival of neurons specifically in populations which are continuously being 
      regenerated in the brain.
FAU - Linnarsson, S
AU  - Linnarsson S
AD  - Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and 
      Biophysics, Karolinska Institute, Doktorsringen 12A, 171 77, Stockholm, Sweden.
FAU - Willson, C A
AU  - Willson CA
FAU - Ernfors, P
AU  - Ernfors P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Brain-Derived Neurotrophic Factor/deficiency/genetics/*physiology
MH  - Cell Survival
MH  - Cerebral Ventricles/cytology/growth & development/*physiology
MH  - Dentate Gyrus/cytology/growth & development/*physiology
MH  - In Situ Nick-End Labeling
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Regeneration/*physiology
MH  - Neurons/*cytology/physiology
MH  - Olfactory Bulb/cytology/growth & development/*physiology
EDAT- 2000/01/29 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0169328X99002958 [pii]
AID - 10.1016/s0169-328x(99)00295-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2000 Jan 10;75(1):61-9. doi: 
      10.1016/s0169-328x(99)00295-8.