PMID- 10649626
OWN - NLM
STAT- MEDLINE
DCOM- 20000322
LR  - 20220318
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 18
IP  - 13
DP  - 2000 Jan 18
TI  - Effect of vaccination on the potentiation of porcine reproductive and respiratory 
      syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae.
PG  - 1244-52
AB  - Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma 
      hyopneumoniae are frequently isolated pathogens from pigs with respiratory 
      disease. A previous study conducted in our laboratory found that infection with 
      M. hyopneumoniae increased the duration and severity of respiratory disease 
      induced by PRRSV. The purpose of this experiment was to determine whether 
      vaccination against M. hyopneumoniae and/or PRRSV decreased the enhancement of 
      PRRSV-induced pneumonia. Both M. hyopneumoniae bacterin and PRRSV vaccine 
      decreased the severity of clinical respiratory disease. Infection or vaccination 
      with PRRSV appeared to decrease the efficacy of the M. hyopneumoniae bacterin. 
      Vaccination with M. hyopneumoniae bacterin decreased the potentiation of 
      PRRSV-induced pneumonia observed in the dual infected pigs. However, PRRSV 
      vaccination in combination with M. hyopneumoniae bacterin eliminated this benefit 
      and the amount of pneumonia induced by PRRSV increased. PRRSV vaccine alone did 
      not decrease the potentiation of PRRSV pneumonia by M. hyopneumoniae.
FAU - Thacker, E L
AU  - Thacker EL
AD  - Veterinary Medical Research Institute, Iowa State University, Ames 50011, USA. 
      ethacker@iastate.edu
FAU - Thacker, B J
AU  - Thacker BJ
FAU - Young, T F
AU  - Young TF
FAU - Halbur, P G
AU  - Halbur PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/biosynthesis/blood
MH  - Antibody Specificity
MH  - Bacterial Vaccines/immunology/*therapeutic use
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Immunoglobulin G/biosynthesis/blood
MH  - Lung/immunology/microbiology/pathology/virology
MH  - Mycoplasma/*immunology/isolation & purification
MH  - Pneumonia of Swine, Mycoplasmal/immunology/prevention & control/*veterinary
MH  - Pneumonia, Viral/immunology/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/microbiology/prevention 
      & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/isolation & 
      purification
MH  - Random Allocation
MH  - Swine
MH  - Swine Diseases/immunology/microbiology/*prevention & control
MH  - Viral Vaccines/immunology/*therapeutic use
EDAT- 2000/01/29 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0264-410X(99)00395-3 [pii]
AID - 10.1016/s0264-410x(99)00395-3 [doi]
PST - ppublish
SO  - Vaccine. 2000 Jan 18;18(13):1244-52. doi: 10.1016/s0264-410x(99)00395-3.