PMID- 10650487
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20070621
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 32
IP  - 4
DP  - 1999 Dec
TI  - Tumor necrosis factor-alpha and interleukin-6 profiles in children with 
      pneumonia.
PG  - 233-8
AB  - Pneumonia is a common cause of hospitalization and is associated with high 
      morbidity in children. Tumor necrosis factor-alpha (TNF-alpha) and Interleukin-6 
      (IL-6) are primary mediators of inflammation, and have been implicated in a large 
      number of infectious and non-infectious inflammatory diseases. The serum 
      concentrations of TNF-alpha and IL-6 were measured by enzyme-linked immunosorbent 
      assay (ELISA) in 27 patients with bacterial pneumonia (n = 12) or respiratory 
      syncytial virus (RSV) pneumonia (n = 15) and in 15 healthy control subjects. 
      TNF-alpha concentrations of patients with bacterial pneumonia in acute stage 
      (16.94 +/- 5.70 ng/L) were significantly higher than those in convalescent stage 
      (5.80 +/- 0.75 ng/L), in patients with RSV pneumonia (5.06 +/- 0.44 ng/L) and in 
      healthy control subjects (5.39 +/- 0.68 ng/L) (p < 0.005). TNF-alpha 
      concentrations of patients with RSV pneumonia were not significantly different 
      from those of the control group. IL-6 concentrations of patients with bacterial 
      pneumonia in acute stage (465.94 +/- 290.30 ng/L) were significantly higher than 
      those in convalescent stage (22.04 +/- 15.08 ng/L), in patients with RSV 
      pneumonia (7.65 +/- 2.58 ng/L), and in healthy control subjects (0.84 +/- 0.08 
      ng/L) (p < 0.0005). There was significant difference between patients with RSV 
      pneumonia and the healthy control group (p < 0.005). In summary, there were 
      significant differences in TNF-alpha and IL-6 concentrations between acute stage 
      and convalescent stage in patients with bacterial pneumonia, making them useful 
      as markers for bacterial pneumonia. Further studies are needed to establish the 
      potential diagnostic and prognostic value of TNF-alpha and IL-6.
FAU - Wang, C M
AU  - Wang CM
AD  - Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, ROC.
FAU - Tang, R B
AU  - Tang RB
FAU - Chung, R L
AU  - Chung RL
FAU - Hwang, B T
AU  - Hwang BT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interleukin-6/*blood
MH  - Male
MH  - Pneumonia, Bacterial/*immunology
MH  - Pneumonia, Viral/*immunology
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2000/01/29 00:00
MHDA- 2000/01/29 00:01
CRDT- 2000/01/29 00:00
PHST- 2000/01/29 00:00 [pubmed]
PHST- 2000/01/29 00:01 [medline]
PHST- 2000/01/29 00:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 1999 Dec;32(4):233-8.