PMID- 10651313
OWN - NLM
STAT- MEDLINE
DCOM- 20000207
LR  - 20191024
IS  - 0262-0898 (Print)
IS  - 0262-0898 (Linking)
VI  - 17
IP  - 5
DP  - 1999 Jul
TI  - In vivo treatment of rats with unfractionated heparin (UFH) or low molecular 
      weight heparin (LMWH) does not affect experimentally induced colon carcinoma 
      metastasis.
PG  - 451-6
AB  - Recent randomized trials have suggested that treatment with low molecular weight 
      heparin (LMWH) improves survival of cancer patients with venous thromboembolism, 
      as compared to treatment with unfractionated heparin (UFH). Experimental studies 
      have shown that UFH has activities besides its anticoagulant function which may 
      affect progression of malignancy, including stimulation of new blood vessel 
      formation. In contrast, LMWH has been suggested to inhibit angiogenesis. In the 
      present study, we compared quantitatively the effects of treatment with UFH, LMWH 
      or placebo on the development of experimentally induced colon carcinoma 
      metastases in rat liver and on tumor-associated angiogenesis. It is shown that 
      UFH and LMWH in therapeutic dosages neither affect development of metastases nor 
      tumor blood vessel formation in this animal model. These results indicate that 
      heparins do not affect colon cancer metastasis in liver. Further studies in other 
      animal models are required to establish the mechanisms by which heparins 
      potentially affect cancer.
FAU - Smorenburg, S M
AU  - Smorenburg SM
AD  - Academic Medical Center, University of Amsterdam, Department of Cell Biology and 
      Histology, The Netherlands. s.m.smorenburg@amc.uva.nl
FAU - Vink, R
AU  - Vink R
FAU - te Lintelo, M
AU  - te Lintelo M
FAU - Tigchelaar, W
AU  - Tigchelaar W
FAU - Maas, A
AU  - Maas A
FAU - Buller, H R
AU  - Buller HR
FAU - van Noorden, C J
AU  - van Noorden CJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Exp Metastasis
JT  - Clinical & experimental metastasis
JID - 8409970
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Anticoagulants/adverse effects/*therapeutic use
MH  - Colonic Neoplasms/blood supply/*drug therapy/*pathology
MH  - Heparin/adverse effects/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/adverse effects/*therapeutic use
MH  - Humans
MH  - Neoplasm Metastasis/prevention & control
MH  - *Neovascularization, Pathologic
MH  - Rats
EDAT- 2000/01/29 00:00
MHDA- 2000/01/29 00:01
CRDT- 2000/01/29 00:00
PHST- 2000/01/29 00:00 [pubmed]
PHST- 2000/01/29 00:01 [medline]
PHST- 2000/01/29 00:00 [entrez]
AID - 10.1023/a:1006648429914 [doi]
PST - ppublish
SO  - Clin Exp Metastasis. 1999 Jul;17(5):451-6. doi: 10.1023/a:1006648429914.