PMID- 10651735
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 108
IP  - 1
DP  - 2000 Jan
TI  - High levels of antiphospholipid antibodies are associated with cytomegalovirus 
      infection in unrelated bone marrow and cord blood allogeneic stem cell 
      transplantation.
PG  - 126-31
AB  - Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune 
      immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory 
      test systems. These antibodies have been associated with several conditions 
      (malignancies, autoimmune diseases, infections, use of drugs); moreover, a 
      syndrome capable of inducing thromboembolic disease has recently been associated 
      with the presence of these antibodies. The aim of this prospective study was to 
      investigate the levels of APA in subjects affected by haematological malignancies 
      undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between 
      March 1996 and December 1997, 32 patients undergoing ASCT were studied 
      prospectively until day +180 from transplant. The mean values of IgG and IgM 
      anticardiolipin antibodies (ACA) increased in recipients of stem cells from 
      anunrelated donor, and a statistically significant difference inACA IgG mean 
      value between unrelated and related transplanted patients was demonstrated 
      between days +95 and +180. All of the subjects who received stem cells from an 
      unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of 
      those receiving stem cells from a related donor (P < 0.01). The reason for such a 
      difference may be a result of the different incidence in documented 
      cytomegalovirus (CMV) infection in the two groups (83% vs. 23%; P < 0.01), as 
      indicated by the significant correlation between APA positivity and CMV infection 
      (P < 0.05). No relationship was found between APA, conditioning regimen and acute 
      or chronic graft vs. host disease (GVHD). Moreover, we did not observe any 
      thromboembolic disorder or veno occlusive disease (VOD).
FAU - Mengarelli, A
AU  - Mengarelli A
AD  - Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita 'La Sapienza', 
      Rome, Italy.
FAU - Minotti, C
AU  - Minotti C
FAU - Palumbo, G
AU  - Palumbo G
FAU - Arcieri, P
AU  - Arcieri P
FAU - Gentile, G
AU  - Gentile G
FAU - Iori, A P
AU  - Iori AP
FAU - Arcese, W
AU  - Arcese W
FAU - Mandelli, F
AU  - Mandelli F
FAU - Avvisati, G
AU  - Avvisati G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antiphospholipid/*metabolism
MH  - Bone Marrow Transplantation/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus Infections/*immunology
MH  - Female
MH  - Fetal Blood
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
EDAT- 2000/01/29 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - bjh1812 [pii]
AID - 10.1046/j.1365-2141.2000.01812.x [doi]
PST - ppublish
SO  - Br J Haematol. 2000 Jan;108(1):126-31. doi: 10.1046/j.1365-2141.2000.01812.x.