PMID- 10651858
OWN - NLM
STAT- MEDLINE
DCOM- 20000316
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 12
IP  - 1
DP  - 2000 Jan
TI  - Convergence of segregated pheromonal pathways from the accessory olfactory bulb 
      to the cortex in the mouse.
PG  - 33-46
AB  - The accessory olfactory system mediates intraspecies pheromonal communication. 
      Two subsets of spatially segregated vomeronasal sensory neurons, presumably 
      handling functionally and structurally different sets of ligand molecules, can be 
      distinguished. The two subsets of sensory neurons project their axons to 
      segregated zones of the accessory olfactory bulb (AOB) and connect with zonally 
      separated mitral/tufted (M/T) cells, suggesting that the accessory olfactory 
      system is divided into two distinct pathways up to the level of the AOB. To 
      examine whether the segregation is maintained at the accessory olfactory cortical 
      (AOC) regions, we selectively tracer-labelled mitral/tufted cells located in the 
      rostral, caudal or in both zones of the adult mouse AOB. The results demonstrate 
      that the axonal projection patterns of rostral zone and caudal zone M/T cells 
      were indistinguishable in the AOC regions. Mitral/tufted cell axons from either 
      zone of the AOB covered the entire area of all four AOC regions: the bed nucleus 
      of the accessory olfactory tract, the medial amygdaloid nucleus, the 
      posteromedial cortical amygdaloid nucleus and the bed nucleus of the stria 
      terminalis. Therefore, over the entire area of each AOC region, ensembles of 
      cortical neurons receive input from both zonal subsets of M/T cells of the AOB. 
      However, the present results do not rule out the possibility that individual 
      cortical neurons sample information from M/T cells of a single zone. These 
      results are consistent with the idea that the segregation of zonal pathways 
      collapses in the AOC regions. Clusters of cortical neurons in each AOC region may 
      combine information from both families of pheromone receptors and thus handle 
      signals from structurally and functionally different categories of pheromone 
      molecules.
FAU - von Campenhausen, H
AU  - von Campenhausen H
AD  - 1Laboratory for Neuronal Recognition Molecules, Brain Science Institute, RIKEN, 
      2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
FAU - Mori, K
AU  - Mori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Pheromones)
SB  - IM
MH  - Animals
MH  - Axonal Transport
MH  - Axons/physiology
MH  - Cerebral Cortex/cytology/*physiology
MH  - Chemoreceptor Cells/*physiology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurons, Afferent/cytology/*physiology
MH  - Olfactory Bulb/cytology/*physiology
MH  - Olfactory Pathways/cytology/*physiology
MH  - Pheromones/*physiology
EDAT- 2000/01/29 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - ejn879 [pii]
AID - 10.1046/j.1460-9568.2000.00879.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2000 Jan;12(1):33-46. doi: 10.1046/j.1460-9568.2000.00879.x.