PMID- 10652420
OWN - NLM
STAT- MEDLINE
DCOM- 20000303
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 85
IP  - 3
DP  - 2000 Feb 1
TI  - Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on 
      non-Hodgkin lymphoma incidence in southwestern Japan.
PG  - 319-24
AB  - The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of 
      total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in 
      southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is 
      endemic. The first study area comprised 4 towns located on the K Islands, which 
      had a population of 26,870 in 1990. The overall HTLV-I seroprevalence estimated 
      from the serologic survey of 18,485 subjects was 16.2%. By using the data from 
      the Nagasaki Prefectural Cancer Registry (NPCR) and reviewing clinical and 
      laboratory information, we identified 40 cases of ATL and 35 cases of other NHL 
      diagnosed between 1985 and 1995. The crude annual incidence of ATL among 100,000 
      HTLV-I carriers aged 30 or older was estimated at 137.7 for men and 57.4 for 
      women, with a significant sex difference after adjustment for age (rate ratio = 
      2.50, 95% confidence interval 1.32-4.73). The cumulative risk from 30 to 79 years 
      of age was estimated at approximately 6.6% for men and 2.1% for women. Among the 
      entire population, ATL accounted for 51 to 59% of the total NHL incidence, 
      showing the strong impact of HTLV-I infection. The second study area comprised 
      the whole of Nagasaki Prefecture (total population in 1990 = 1.56 million). 
      Between 1985 and 1995, 989 cases of ATL and 1,745 cases of other NHL were 
      registered in the NPCR. The world age-standardized annual incidence rate of ATL 
      per 100,000 persons aged 30 or older was estimated at 10.5 for men and 6.0 for 
      women, which accounted for approximately 37 to 41% of the total NHL incidence.
FAU - Arisawa, K
AU  - Arisawa K
AD  - Department of Preventive Medicine and Health Promotion, Nagasaki University 
      School of Medicine, Japan. k-iwata@net.nagasaki-u.ac.jp
FAU - Soda, M
AU  - Soda M
FAU - Endo, S
AU  - Endo S
FAU - Kurokawa, K
AU  - Kurokawa K
FAU - Katamine, S
AU  - Katamine S
FAU - Shimokawa, I
AU  - Shimokawa I
FAU - Koba, T
AU  - Koba T
FAU - Takahashi, T
AU  - Takahashi T
FAU - Saito, H
AU  - Saito H
FAU - Doi, H
AU  - Doi H
FAU - Shirahama, S
AU  - Shirahama S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Viral/blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Japan/epidemiology
MH  - Leukemia, T-Cell/*epidemiology/virology
MH  - Lymphoma, Non-Hodgkin/*epidemiology/virology
MH  - Lymphoma, T-Cell/*epidemiology/virology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk
MH  - Sex Distribution
EDAT- 2000/02/01 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/01 09:00
PHST- 2000/02/01 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/01 09:00 [entrez]
AID - 10.1002/(SICI)1097-0215(20000201)85:3<319::AID-IJC4>3.0.CO;2-B [pii]
AID - 10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc4>3.0.co;2-b [doi]
PST - ppublish
SO  - Int J Cancer. 2000 Feb 1;85(3):319-24. doi: 
      10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc4>3.0.co;2-b.