PMID- 10652700
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20151119
IS  - 0024-7766 (Print)
IS  - 0024-7766 (Linking)
VI  - 32
IP  - 4
DP  - 1999 Dec
TI  - Effect of tumor necrosis factor-alpha and interleukin-2 on spleen lymphocyte 
      migration in mouse skin.
PG  - 166-70
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) are reported to 
      enhance lymphocyte binding to endothelial cells in vitro. We examined these two 
      agents on lymphocyte migration in vivo. Spleen lymphocytes were radiolabeled with 
      tritiated uridine (3H-UR) and then injected i.v. into mice. Each cytokine 
      (TNF-alpha or IL-2) or both cytokines were then injected intradermally on the 
      back of mice. The results demonstrated that TNF-alpha stimulates lymphocyte 
      migration in vivo in dose-dependent fashion. Kinetic analysis demonstrated that 
      migration with TNF-alpha started at 3 h, peaked at 6 h, followed by a gradual 
      decline back to baseline at 24 h. IL-2, on the other hand, was nearly inactive, 
      and did not augment lymphocyte migration over and above that induced by TNF-alpha 
      when both cytokines were injected together.
FAU - Sun, J
AU  - Sun J
AD  - Department of Anatomy, Shandong Medical University, Jinan, People's Republic of 
      China.
FAU - Liu, Z
AU  - Liu Z
FAU - Bi, Y
AU  - Bi Y
FAU - Guo, Z
AU  - Guo Z
FAU - Hua, T
AU  - Hua T
FAU - Ding, Z
AU  - Ding Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lymphology
JT  - Lymphology
JID - 0155112
RN  - 0 (Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 10028-17-8 (Tritium)
RN  - WHI7HQ7H85 (Uridine)
SB  - IM
MH  - Animals
MH  - Cell Movement/*immunology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Female
MH  - Interleukin-2/immunology/*pharmacology
MH  - Lymphocytes/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Spleen/*immunology
MH  - Tritium
MH  - Tumor Necrosis Factor-alpha/immunology/*pharmacology
MH  - Uridine
EDAT- 2000/02/01 00:00
MHDA- 2000/02/01 00:01
CRDT- 2000/02/01 00:00
PHST- 2000/02/01 00:00 [pubmed]
PHST- 2000/02/01 00:01 [medline]
PHST- 2000/02/01 00:00 [entrez]
PST - ppublish
SO  - Lymphology. 1999 Dec;32(4):166-70.