PMID- 10654198
OWN - NLM
STAT- MEDLINE
DCOM- 20000307
LR  - 20061115
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 13
IP  - 5
DP  - 1999 Sep-Oct
TI  - Possible role of HHV-6 in the enhanced severity of HSV-1 keratitis.
PG  - 427-32
AB  - Rabbits were divided into three groups and infected with Human Herpesvirus Type 6 
      (HHV-6) or Herpes Simplex Virus Type 1 (HSV 1). Infected eyes were swabbed and 
      cultured every alternate day. At day 15 postinfection (PI), rabbits were 
      sacrificed, trigeminal ganglia (TG) and corneas were analyzed for the presence or 
      absence of viral DNA. The severity of keratitis was much greater in the eyes 
      inoculated by both viruses and cultures from these animals were HSV-1 positive 
      for 15 days PI as compared to 9 days PI for rabbits infected with HSV-1 alone. 
      The corneas from infected eyes and the corresponding TGs from animals infected 
      with HSV-1 were positive for HSV-1 DNA. HHV-6 DNA was recoverable from corneas of 
      infected eyes, but not from the corresponding TGs. Although preliminary, these 
      observations indicate that HHV-6 may enhance the HSV-1 expression in animals with 
      dual infections.
FAU - Qavi, H B
AU  - Qavi HB
AD  - Department of Biochemistry, College of Science, King Saud University, Riyadh, 
      Saudi Arabia. jafari@ksu.edu.sa
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
SB  - IM
MH  - Animals
MH  - Female
MH  - Herpes Simplex/pathology/physiopathology/*virology
MH  - Herpesviridae Infections/pathology/physiopathology/*virology
MH  - *Herpesvirus 1, Human/genetics
MH  - *Herpesvirus 6, Human/genetics
MH  - Humans
MH  - Keratitis, Herpetic/pathology/physiopathology/*virology
MH  - Rabbits
EDAT- 2000/02/02 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/02 09:00
PHST- 2000/02/02 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/02 09:00 [entrez]
PST - ppublish
SO  - In Vivo. 1999 Sep-Oct;13(5):427-32.