PMID- 10656135
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20131121
IS  - 0233-528X (Print)
IS  - 0233-528X (Linking)
VI  - 33
IP  - 6
DP  - 1999
TI  - [Changes in the NO-dependent regulation of the local cerebral blood flow in rats 
      during adaptation to the conditions of simulated weightlessness].
PG  - 42-6
AB  - The nitrogen oxide NO-dependent regulation of the cerebral blood flow was studied 
      before and after 24-hr head-down immobilization (HDI) of intact and pre-trained 
      rats. Training consisted in 2-hr tail-suspension each day of the 2-wk period. 
      Blood flow was determined with the laser Doppler flowmetry following local 
      injection of a NO synthesis blocker (L-NAME), and NO (sodium nitroprusside). 
      Neither HDI nor pre-training per se influenced NO tonic production in the cortex 
      of large hemispheres and cerebellum. However, in pre-trained animals HDI resulted 
      in a significant blood flow response to the local blockade of NO synthesis in the 
      cerebellum. None of the animals changed the reaction of the blood flow to the 
      local injection of sodium nitroprusside. The conclusion was drawn that alteration 
      in the NO-dependent regulation of the brain blood flow in pre-trained animals 
      could manifest of adaptation to HDI in the course of 24-hr suspension.
FAU - Medvedev, O S
AU  - Medvedev OS
FAU - Bychkova, E Iu
AU  - Bychkova EIu
FAU - Zaretskii, D V
AU  - Zaretskii DV
FAU - Murashev, A N
AU  - Murashev AN
FAU - Zaretskaia, M V
AU  - Zaretskaia MV
FAU - Seleznev, D M
AU  - Seleznev DM
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Izmenenie NO-zavisimoi reguliatsii lokal'nogo mozgovogo krovotoka krys pri 
      adaptatsii k usloviiam modelirovannoi nevesomosti.
PL  - Russia (Federation)
TA  - Aviakosm Ekolog Med
JT  - Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental 
      medicine
JID - 9305904
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Nitric Oxide Donors)
RN  - 169D1260KM (Nitroprusside)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - *Adaptation, Physiological/drug effects
MH  - Animals
MH  - Cerebrovascular Circulation/drug effects/*physiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Head-Down Tilt/physiology
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/*physiology
MH  - Nitric Oxide Donors/pharmacology
MH  - Nitric Oxide Synthase/antagonists & inhibitors
MH  - Nitroprusside/pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - *Weightlessness Simulation
EDAT- 2000/02/03 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/03 09:00
PHST- 2000/02/03 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/03 09:00 [entrez]
PST - ppublish
SO  - Aviakosm Ekolog Med. 1999;33(6):42-6.