PMID- 10658973
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20201219
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 61
IP  - 1
DP  - 2000 Jan
TI  - Paired inhibitory and triggering NK cell receptors for HLA class I molecules.
PG  - 7-17
AB  - Human natural killer (NK) cells specifically interact with major 
      histocompatibility complex (MHC) class I molecules employing different receptor 
      systems, shared with subsets of alphabeta and gammadelta T lymphocytes. Killer 
      cell immunoglobulin-like receptors (KIRs) recognize groups of human leukocyte 
      antigen (HLA) class Ia proteins displaying common structural features at the 
      alpha-1 domain; among them, KIR2DL4 has been proposed to specifically interact 
      with the class Ib molecule HLA-G1. Members of a related family of immunoglobulin 
      (Ig)-like receptors (ILT2 or LIR-1 and ILT4 or LIR-2), expressed by other 
      leukocyte lineages, interact with a broad spectrum of class Ia molecules and 
      HLA-G1. On the other hand, CD94/NKG2-A(-C) and NKG2D lectin-like receptors, 
      respectively, recognize the class Ib molecules HLA-E and MICA. A recurrent 
      finding within the different receptor families is the existence of pairs of 
      homologous molecules that often share the same ligands but display divergent 
      functions. Inhibitory receptors tend to exhibit an affinity for HLA molecules 
      higher than their activating counterparts. Recruitment of SH2 domain-bearing 
      tyrosine phosphatases (SHP) by cytoplasmic phosphorylated immunoreceptor 
      tyrosine-based inhibition motifs (ITIMs) is a crucial event for the inhibitory 
      signalling pathway. By contrast, triggering receptors assemble with homodimers of 
      immune tyrosine-based activation motif (ITAM)-bearing adaptor molecules (i.e., 
      DAP12, CD3 xi) that engage tyrosine kinases (ZAP70 and syk).
FAU - Lopez-Botet, M
AU  - Lopez-Botet M
AD  - Servicio de Immunologia, Hospital Universitario de la Princesa, Madrid, Spain. 
      mlbotet@hup.es
FAU - Bellon, T
AU  - Bellon T
FAU - Llano, M
AU  - Llano M
FAU - Navarro, F
AU  - Navarro F
FAU - Garcia, P
AU  - Garcia P
FAU - de Miguel, M
AU  - de Miguel M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL4)
SB  - IM
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Leukocytes/immunology
MH  - Ligands
MH  - Receptors, Immunologic/classification/genetics/immunology/*metabolism
MH  - Receptors, KIR
MH  - Receptors, KIR2DL4
RF  - 108
EDAT- 2000/02/05 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - S0198885999001615 [pii]
AID - 10.1016/s0198-8859(99)00161-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2000 Jan;61(1):7-17. doi: 10.1016/s0198-8859(99)00161-5.