PMID- 10659299
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20191103
IP  - 30
DP  - 1999 Jul
TI  - Effect of diet on thoroughbred horses with recurrent exertional rhabdomyolysis 
      performing a standardised exercise test.
PG  - 458-62
AB  - Previous studies have associated recurrent exertional rhabdomyolysis (RER) with a 
      diet high in soluble carbohydrate (CHO). The purpose of this study was to 
      investigate the effect of 3 diets on clinical and metabolic parameters in 5 
      Thoroughbred horses with RER and 3 healthy Thoroughbreds performing a 
      standardised exercise test (SET). Two diets were formulated to meet energy 
      requirements for the amount of exercise being performed in the form of CHO or fat 
      (21.4 Mcal DE/day). The third diet was formulated to provide 135% of the DE of 
      the other 2 diets in the form of an excessive amount of carbohydrate (28.8 Mcal 
      DE/day). Diets were fed in a crossover design for 3 week blocks and then horses 
      performed a near maximal SET. Changes in heart rate (HR), plasma lactate, plasma 
      glucose, total plasma solids, packed cell volume (PCV), muscle lactate and muscle 
      glycogen concentration were measured immediately prior to, during, and 5 min 
      after exercise. Serum creatine kinase (CK) activity was measured prior to and 4 h 
      post SET. A 2-way ANOVA was used to examine the effect of group and dietary 
      treatment. When dietary treatments were compared, horses fed the high-CHO diet 
      had a mean pre-SET PCV and pre-SET HR that was higher than horses fed the fat 
      diet (P = 0.06 and P = 0.07, respectively). Pre-SET heart rates were highest in 
      RER horses consuming the high-CHO diet compared to RER horses consuming the 
      low-CHO and fat diets (P = 0.02). Horses with RER had 4 h post SET CK activity 
      greater than 400 u/l in 7/14 (50%) measurements compared to control horses which 
      had CK activity greater than 400 u/l in 2/7 (29%) measurements. This study did 
      not demonstrate a significant effect of diet on rhabdomyolysis, indicated by CK 
      activity, or on the metabolic response to exercise. However, diet may have a 
      calming effect on Thoroughbred horses with RER as manifested by decreased 
      pre-exercise heart rates and decreased pre-exercise PCV in horses fed the fat 
      diet.
FAU - MacLeay, J M
AU  - MacLeay JM
AD  - Department of Clinical and Population Sciences, University of Minnesota, St. Paul 
      55108, USA.
FAU - Valberg, S J
AU  - Valberg SJ
FAU - Pagan, J D
AU  - Pagan JD
FAU - de laCorte, F
AU  - de laCorte F
FAU - Roberts, J
AU  - Roberts J
FAU - Billstrom, J
AU  - Billstrom J
FAU - McGinnity, J
AU  - McGinnity J
FAU - Kaese, H
AU  - Kaese H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Equine Vet J Suppl
JT  - Equine veterinary journal. Supplement
JID - 9614088
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Creatine Kinase/blood
MH  - *Diet
MH  - Dietary Carbohydrates/administration & dosage
MH  - Exercise Test/veterinary
MH  - Female
MH  - Glycogen/metabolism
MH  - Heart Rate
MH  - Hematocrit
MH  - Horse Diseases/blood/*physiopathology
MH  - Horses
MH  - Lactic Acid/metabolism
MH  - Medicago sativa
MH  - Muscles/metabolism
MH  - *Physical Conditioning, Animal
MH  - Rhabdomyolysis/*veterinary
EDAT- 2000/02/05 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - 10.1111/j.2042-3306.1999.tb05265.x [doi]
PST - ppublish
SO  - Equine Vet J Suppl. 1999 Jul;(30):458-62. doi: 
      10.1111/j.2042-3306.1999.tb05265.x.