PMID- 10659850
OWN - NLM
STAT- MEDLINE
DCOM- 20000211
LR  - 20061115
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 403
IP  - 6767
DP  - 2000 Jan 20
TI  - Functional regeneration of sensory axons into the adult spinal cord.
PG  - 312-6
AB  - The arrest of dorsal root axonal regeneration at the transitional zone between 
      the peripheral and central nervous system has been repeatedly described since the 
      early twentieth century. Here we show that, with trophic support to damaged 
      sensory axons, this regenerative barrier is surmountable. In adult rats with 
      injured dorsal roots, treatment with nerve growth factor (NGF), neurotrophin-3 
      (NT3) and glial-cell-line-derived neurotrophic factor (GDNF), but not 
      brain-derived neurotrophic factor (BDNF), resulted in selective regrowth of 
      damaged axons across the dorsal root entry zone and into the spinal cord. Dorsal 
      horn neurons were found to be synaptically driven by peripheral nerve stimulation 
      in rats treated with NGF, NT3 and GDNF, demonstrating functional reconnection. In 
      behavioural studies, rats treated with NGF and GDNF recovered sensitivity to 
      noxious heat and pressure. The observed effects of neurotrophic factors 
      corresponded to their known actions on distinct subpopulations of sensory 
      neurons. Neurotrophic factor treatment may thus serve as a viable treatment in 
      promoting recovery from root avulsion injuries. I
FAU - Ramer, M S
AU  - Ramer MS
AD  - Neuroscience Research Centre, Guy's, King's and St. Thomas' School of Biomedical 
      Sciences, London, UK. matt.ramer@kcl.ac.uk
FAU - Priestley, J V
AU  - Priestley JV
FAU - McMahon, S B
AU  - McMahon SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
CIN - Nature. 2000 Jan 20;403(6767):257, 259-60. PMID: 10659832
MH  - Afferent Pathways
MH  - Animals
MH  - Axons/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Nerve Crush
MH  - Nerve Fibers, Myelinated/drug effects/physiology
MH  - Nerve Growth Factor/pharmacology
MH  - Nerve Growth Factors/*pharmacology
MH  - *Nerve Regeneration
MH  - Nerve Tissue Proteins/pharmacology
MH  - Neurons, Afferent/drug effects/physiology
MH  - Neurotrophin 3/pharmacology
MH  - Pain
MH  - Peripheral Nerves/physiology
MH  - Posterior Horn Cells/cytology/drug effects/*physiology
MH  - Rats
MH  - Rhizotomy
MH  - Spinal Cord/cytology/drug effects/*physiology
MH  - Spinal Nerve Roots/drug effects/*physiology
MH  - Synaptic Transmission/drug effects
EDAT- 2000/02/05 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/02/05 09:00
PHST- 2000/02/05 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/02/05 09:00 [entrez]
AID - 10.1038/35002084 [doi]
PST - ppublish
SO  - Nature. 2000 Jan 20;403(6767):312-6. doi: 10.1038/35002084.