PMID- 10660875
OWN - NLM
STAT- MEDLINE
DCOM- 20000218
LR  - 20061115
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 416
IP  - 4
DP  - 2000 Jan 24
TI  - RXR gamma gene is expressed by discrete cell columns within the alar plate of the 
      brainstem of the chicken embryo.
PG  - 417-28
AB  - With in situ hybridization assays, we mapped the distribution of retinoid X 
      receptor gamma (RXR gamma) gene transcripts in the central nervous system of the 
      chicken embryo. Previous studies have demonstrated the presence of RXR gamma 
      transcripts in migrating neural crest and in neural crest derivatives throughout 
      the peripheral nervous system, implicating RXR gamma as an early pan-neural crest 
      marker (Rowe et al. 1991. Development 111:771-778), and in the retina (Hoover et 
      al. 1998. J Comp Neurol 391:204-213). Here we report the presence of RXR gamma 
      transcripts in discrete regions of the developing neural tube, within the 
      hindbrain, the cerebellar plate, the optic tectum, and the diencephalon. At stage 
      10, when migrating neural crest expresses RXR gamma transcripts, we detect no 
      transcripts in the neural tube. By stage 13, RXR gamma transcripts accumulate to 
      detectable levels along the midline of the posterior optic tectum, where the 
      neural crest-derived sensory neurons of the mesencephalic trigeminal nucleus are 
      located. By stage 15, RXR gamma transcripts also appear in an intermittent 
      longitudinal cell column within the mantle zone of the alar plate of the 
      hindbrain, eventually extending into the cerebellar plate rostrally and into the 
      cervical spinal cord caudally, with a gap at about rhombomere 3. By stage 19, 
      transcripts appear in a discrete population of cells within the diencephalon. 
      Expression in these cell populations continues until at least stage 22.5, when 
      many neuron populations have been generated in the hindbrain. The localization of 
      the RXR gamma-positive cells to the mantle zone suggests that they are 
      postmitotic and are probably neurons. Their specific alar locations indicate that 
      they reside within sensory columns and potential downstream targets, evidently 
      corresponding to some of the central components of the trigeminal system.
FAU - Hoover, F
AU  - Hoover F
AD  - Department of Physiology, University of Oslo, Norway.
FAU - Kielland, A
AU  - Kielland A
FAU - Glover, J C
AU  - Glover JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Brain Stem/*embryology
MH  - Central Nervous System/embryology
MH  - Chick Embryo
MH  - *Gene Expression
MH  - Neurons/metabolism
MH  - Receptors, Retinoic Acid/*genetics/metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factors/*genetics/metabolism
MH  - Trigeminal Nerve/embryology
EDAT- 2000/02/08 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/08 09:00
PHST- 2000/02/08 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/08 09:00 [entrez]
AID - 10.1002/(SICI)1096-9861(20000124)416:4<417::AID-CNE1>3.0.CO;2-6 [pii]
PST - ppublish
SO  - J Comp Neurol. 2000 Jan 24;416(4):417-28.