PMID- 10661491
OWN - NLM
STAT- MEDLINE
DCOM- 20000222
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 852
IP  - 1
DP  - 2000 Jan 3
TI  - In situ and immunocytochemical localization of E-FABP mRNA and protein during 
      neuronal migration and differentiation in the rat brain.
PG  - 16-27
AB  - The present study compares the temporal-spatial expression and tissue 
      localization of the rat epidermal type fatty acid binding protein (E-FABP) 
      (DA11/C-FABP/S-FABP/LEBP/KLBP) in the developing rat central nervous system 
      (CNS). In situ hybridization (ISH) and immunocytochemistry (ICC) studies 
      demonstrate that mRNA E-FABP and protein are expressed at high levels during 
      neurogenesis, neuronal migration, and terminal differentiation. Migrating 
      pyramidal cells in the cerebral cortex, Purkinje cells and deep nuclear neurons 
      in the cerebellum, and neurons in the olfactory bulb and retina exhibited a 
      strong E-FABP-like immunoreactivity (E-FABP-LI) throughout the entire process of 
      differentiation and migration. The levels of E-FABP mRNA and protein were 
      dramatically higher in prenatal and early postnatal neurons, as compared to adult 
      neurons. The E-FABP antibody immunoreacted with growing neurites, and nuclear and 
      cytoplasmic regions of neurons. The intracellular multiregional pattern of 
      localization of E-FABP and its differential temporal expression during 
      development, are consistent with its proposed role in transporting long chain 
      free fatty acids and/or other hydrophobic ligands during neuronal differentiation 
      and axon growth.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Physiology and Pharmacology, School of Medicine, Loma Linda 
      University, CA 92354, USA.
FAU - Longo, L D
AU  - Longo LD
FAU - De Leon, M
AU  - De Leon M
LA  - eng
GR  - R01-HD03807/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Carrier Proteins)
RN  - 0 (Fabp7 protein, rat)
RN  - 0 (Fatty Acid-Binding Protein 7)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Myelin P2 Protein)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain/*embryology/growth & development/metabolism
MH  - Carrier Proteins/*genetics/*metabolism
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cerebellum/embryology
MH  - Embryonic and Fetal Development
MH  - Fatty Acid-Binding Protein 7
MH  - Fatty Acid-Binding Proteins
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Myelin P2 Protein/*genetics/*metabolism
MH  - Neocortex/embryology
MH  - *Neoplasm Proteins
MH  - *Nerve Tissue Proteins
MH  - Neurons/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retina/embryology
MH  - Subcellular Fractions/metabolism
EDAT- 2000/02/08 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/08 09:00
PHST- 2000/02/08 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/08 09:00 [entrez]
AID - S0006-8993(99)02158-7 [pii]
AID - 10.1016/s0006-8993(99)02158-7 [doi]
PST - ppublish
SO  - Brain Res. 2000 Jan 3;852(1):16-27. doi: 10.1016/s0006-8993(99)02158-7.