PMID- 10664677
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20061115
IS  - 0011-4529 (Print)
IS  - 0011-4529 (Linking)
VI  - 96
IP  - 383
DP  - 1998
TI  - Evaluation of monocyte chemotactic responsiveness in uraemic patients undergoing 
      haemodialysis with different dialytic membranes.
PG  - 171-8
AB  - Recent data show that monocyte chemotactic peptide-1 (MCP-1), a chemotactic 
      factor specific for monocytes, may play a central role in regulating the 
      activation of these cells. For this reason, the production of MCP-1 in peripheral 
      blood mononuclear cell (PBMC) cultures of eight healthy subjects, six chronic 
      uraemic subjects under conservative treatment and six chronic uraemic patients 
      undergoing haemodialysis (HD), was assessed. In the latter group of individuals, 
      complement-activating membranes such as cuprophan (CU) were used for 1 month 
      followed by biocompatible non-complement-activating membranes, like 
      polymethylmetacrylate (PMMA) for the next 30 days. The chemotactic index (CI) 
      elicited by PBMC supernatants from patients undergoing dialysis was found to be 
      significantly higher than that obtained by supernatants recovered from normal 
      subjects or uraemic patients on conservative therapy. Furthermore, the CI from 
      PBMC supernatants having had contact with CU membranes was higher than that 
      obtained from PBMC activated by PMMA. Finally, the increased chemotactic ability 
      in the supernatants was closely correlated with the augmented MCP-1 gene 
      expression and production, as assessed by in vitro hybridization studies.
FAU - Ventura, M T
AU  - Ventura MT
AD  - Department of Internal Medicine, Immunology and Infectious Diseases, University 
      of Bari Medical School, Italy.
FAU - Di Corato, R
AU  - Di Corato R
FAU - Giuliano, G
AU  - Giuliano G
FAU - Matino, M G
AU  - Matino MG
FAU - Antonaci, S
AU  - Antonaci S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytobios
JT  - Cytobios
JID - 0207227
RN  - 0 (Biocompatible Materials)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Membranes, Artificial)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Adult
MH  - Biocompatible Materials
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - *Chemotaxis, Leukocyte
MH  - Female
MH  - Humans
MH  - In Situ Hybridization
MH  - Kidney Failure, Chronic/*therapy
MH  - Male
MH  - *Membranes, Artificial
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Polymethyl Methacrylate
MH  - Renal Dialysis/*adverse effects
MH  - Uremia/therapy
EDAT- 2000/02/09 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/09 09:00
PHST- 2000/02/09 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/09 09:00 [entrez]
PST - ppublish
SO  - Cytobios. 1998;96(383):171-8.