PMID- 10667228
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 886
DP  - 1999
TI  - Expression of matrix metalloproteinases and their inhibitors in human brain 
      tumors.
PG  - 236-9
AB  - Sixty human brain tumors, including grade I meningiomas, schwannomas, and 
      pilocytic astrocytomas, grade II astrocytomas, grade III anaplastic astrocytomas 
      and oligodendrogliomas, and grade IV glioblastomas and lung and melanoma 
      metastases were analyzed for expression of four matrix metalloproteinases (MMPs), 
      two tissue inhibitors of MMPs (TIMPs), and MMP activity. No marked correlation 
      was found between MMP expression and the degree of malignancy. Western blotting 
      analysis revealed a more uniform pattern of distribution of MMP-2 (gelatinase A) 
      than of MMP-9 (gelatinase B) and MMP-12 (metalloelastase) among tumors. All 60 
      tumors showed a similar pattern of activity in zymography, MMP-2 being the major 
      species detected. Interestingly, TIMP-1 and TIMP-2 expression levels were low in 
      tumors of grade III but significantly higher in tumors of grade I, particularly 
      schwannomas. Altogether, these data suggest that: (1) the balance between MMP-2 
      and TIMP-2 is important in human brain tumors; and (2) TIMP expression may be a 
      valuable marker for tumor malignancy.
FAU - Beliveau, R
AU  - Beliveau R
AD  - Laboratoire de medecine moleculaire, Hopital Ste-Justine-UQAM, Montreal, Quebec, 
      Canada. beliveau.richard@uquam.ca
FAU - Delbecchi, L
AU  - Delbecchi L
FAU - Beaulieu, E
AU  - Beaulieu E
FAU - Mousseau, N
AU  - Mousseau N
FAU - Kachra, Z
AU  - Kachra Z
FAU - Berthelet, F
AU  - Berthelet F
FAU - Moumdjian, R
AU  - Moumdjian R
FAU - Del Maestro, R
AU  - Del Maestro R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Blotting, Western
MH  - Brain Neoplasms/*enzymology/metabolism
MH  - Fluorometry
MH  - Humans
MH  - Matrix Metalloproteinases/*metabolism
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
EDAT- 2000/02/10 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/10 09:00
PHST- 2000/02/10 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/10 09:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb09425.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999;886:236-9. doi: 10.1111/j.1749-6632.1999.tb09425.x.