PMID- 10667498
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20190706
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 28
IP  - 1
DP  - 2000 Jan
TI  - Thermodilution versus inert gas rebreathing for estimation of effective pulmonary 
      blood flow.
PG  - 51-6
AB  - OBJECTIVE: To compare measurements of the effective pulmonary blood flow (Qep, 
      i.e., nonshunted fraction of cardiac output, Qt) by the inert gas rebreathing 
      (RB) method and the thermodilution (TD) technique in critically ill patients. 
      DESIGN: Prospective, comparative study of a noninvasive method and an established 
      invasive technique. SETTING: An 11-bed general intensive care unit in a 
      university hospital. PATIENTS: A total of 14 critically ill patients, all 
      mechanically ventilated and monitored with systemic and pulmonary artery 
      catheters. MEASUREMENTS AND MAIN RESULTS: Qep was determined in duplicate by RB 
      using a mass spectrometer for gas analysis. For each determination, Qt was 
      measured in triplicate by the cold water bolus TD technique and averaged. 
      Simultaneously mixed venous and arterial blood samples were analyzed to calculate 
      the intrapulmonary shunt fraction and thereby convert estimates of Qt to Qep. 
      Mean difference between paired estimates (RB - TD) was 0.01 L/min, so for 
      differences was 1.19 L/min, and 95% confidence interval for the bias was -0.45 to 
      0.47 L/min. Coefficients of variation for repeated Qep estimates were 8% (RB) and 
      12% (TD), respectively. Coefficients of variation for RB estimates of functional 
      residual capacity and lung tissue volume were 6% and 17%, respectively. 
      CONCLUSIONS: The RB method is a promising method for simultaneous noninvasive 
      estimation of Qep and functional residual capacity in mechanically ventilated 
      patients. However, further investigations are needed to evaluate potential 
      problems of the method before it can be recommended for clinical purposes.
FAU - Christensen, P
AU  - Christensen P
AD  - Department of Anesthesiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Clemensen, P
AU  - Clemensen P
FAU - Andersen, P K
AU  - Andersen PK
FAU - Henneberg, S W
AU  - Henneberg SW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Output
MH  - *Critical Care/methods
MH  - Female
MH  - Functional Residual Capacity
MH  - *Hemodynamics
MH  - Humans
MH  - Lung/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Pulmonary Ventilation
MH  - Regional Blood Flow
MH  - Regression Analysis
MH  - *Respiration, Artificial
MH  - Thermodilution
EDAT- 2000/02/10 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/10 09:00
PHST- 2000/02/10 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/10 09:00 [entrez]
AID - 10.1097/00003246-200001000-00008 [doi]
PST - ppublish
SO  - Crit Care Med. 2000 Jan;28(1):51-6. doi: 10.1097/00003246-200001000-00008.