PMID- 10667934
OWN - NLM
STAT- MEDLINE
DCOM- 20000323
LR  - 20190905
IS  - 0090-4341 (Print)
IS  - 0090-4341 (Linking)
VI  - 38
IP  - 3
DP  - 2000 Apr
TI  - Effects of chronic dietary cadmium on hepatic glutathione levels and glutathione 
      peroxidase activity in starlings (Sturnus vulgaris).
PG  - 357-61
AB  - The effects of chronic exposure to dietary cadmium on the levels of hepatic 
      glutathione (GSH) and on the activity of the glutathione peroxidase enzymes 
      (GSH-Px) were studied for the first time in starlings (Sturnus vulgaris). 
      Thirty-three individuals (17 females and 16 males) were divided into three 
      groups: One represented the untreated control and two were respectively fed with 
      diets containing 10 and 50 ppm cadmium chloride (CdCl(2)). The total duration of 
      treatment was 22 weeks. The three groups respectively accumulated mean hepatic Cd 
      residues of 2.29, 75.71, and 208.49 ppm. Hepatic GSH increased in the treated 
      groups respectively 24% and 52% in comparison to controls. Total GSH-Px activity 
      in the liver was inhibited in the group fed with 50 ppm, due to inhibition of the 
      selenium-dependent fraction of the enzyme, while the selenium-independent 
      fraction did not change significantly. During the treatment, after 14 weeks of 
      exposure to cadmium, the 50 ppm-treated group showed a 47% decrease of the 
      activity of the selenium-dependent GSH-Px and a 50% increase of the somatic liver 
      index in comparison with controls.
FAU - Congiu, L
AU  - Congiu L
AD  - Department of Biology, University of Padova, via G. Colombo 3, 45100 Padova, 
      Italy.
FAU - Chicca, M
AU  - Chicca M
FAU - Pilastro, A
AU  - Pilastro A
FAU - Turchetto, M
AU  - Turchetto M
FAU - Tallandini, L
AU  - Tallandini L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Environ Contam Toxicol
JT  - Archives of environmental contamination and toxicology
JID - 0357245
RN  - 0 (Environmental Pollutants)
RN  - 00BH33GNGH (Cadmium)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Cadmium/*adverse effects
MH  - *Diet
MH  - Environmental Pollutants/*adverse effects
MH  - Female
MH  - Glutathione/analysis
MH  - Glutathione Peroxidase/drug effects/*metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Songbirds/*physiology
EDAT- 2000/02/10 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/10 09:00
PHST- 2000/02/10 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/10 09:00 [entrez]
AID - 10.1007/s002449910047 [pii]
AID - 10.1007/s002449910047 [doi]
PST - ppublish
SO  - Arch Environ Contam Toxicol. 2000 Apr;38(3):357-61. doi: 10.1007/s002449910047.