PMID- 10667982
OWN - NLM
STAT- MEDLINE
DCOM- 20000306
LR  - 20190513
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 10
IP  - 2
DP  - 2000 Feb
TI  - Investigation of nonlinear ECoG changes during spontaneous sleep state changes 
      and cortical arousal in fetal sheep.
PG  - 142-8
AB  - We examined the processes of cortical activation and deactivation of the fetal 
      brain during spontaneous sleep state transitions and during central nervous 
      processing of vibroacoustic stimulations (VASs) using nonlinear analysis of the 
      electrocorticogram (ECoG). Tests of nonlinearity and a random shuffling routine 
      revealed deterministic and nonlinear portions in the fetal ECoG. As common 
      nonlinear measures are not applicable to nonstationary time series, we developed 
      an algorithm to estimate the predictability of the ECoG in its time course by 
      means of a point prediction error (PPE). The ECoG was recorded before and during 
      VAS from the maternal abdominal surface in seven chronically instrumented fetal 
      sheep at 0.8 of gestation. The PPE during REM sleep was significantly higher than 
      during NREM sleep. VAS in NREM sleep resulted in an abrupt increase of the PPE 
      not reaching the level of REM sleep. The steep increase of the PPE at onset and 
      its slow decrease after cessation of the stimulus were very similar to the 
      dynamics of spontaneous sleep state transitions, suggesting the involvement of 
      the same cortical activating mechanisms. In conclusion, the stage and the time 
      course of fetal brain activation and deactivation patterns can be clearly shown 
      by PPE techniques. The PPE is a useful complement to spectral analysis. Both 
      techniques describe different properties of the ECoG.
FAU - Schwab, M
AU  - Schwab M
AD  - Department of Neurology, Institute for Medical Statistics, Computer Science and 
      Documentation, Friedrich Schiller University, Jena, Germany.
FAU - Schmidt, K
AU  - Schmidt K
FAU - Witte, H
AU  - Witte H
FAU - Abrams, M
AU  - Abrams M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Alpha Rhythm
MH  - Animals
MH  - Arousal/*physiology
MH  - Beta Rhythm
MH  - Cerebral Cortex/*embryology/physiology
MH  - Delta Rhythm
MH  - *Electroencephalography
MH  - Fetus
MH  - Sheep
MH  - Sleep/*physiology
MH  - Sleep Stages/physiology
MH  - Sleep, REM/physiology
MH  - Theta Rhythm
EDAT- 2000/02/11 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/11 09:00
PHST- 2000/02/11 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/11 09:00 [entrez]
AID - 10.1093/cercor/10.2.142 [doi]
PST - ppublish
SO  - Cereb Cortex. 2000 Feb;10(2):142-8. doi: 10.1093/cercor/10.2.142.