PMID- 10668819
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20190513
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 14
IP  - 1
DP  - 2000 Jan-Feb
TI  - Food hypersensitivity reactions in Soft Coated Wheaten Terriers with 
      protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic 
      food sensitivity testing, dietary provocation, and fecal immunoglobulin E.
PG  - 60-7
AB  - The purpose of this study was to evaluate Soft Coated Wheaten Terriers (SCWTs) 
      affected with protein-losing enteropathy (PLE) or protein-losing nephropathy 
      (PLN) or both for allergy to food. We performed gastroscopic food-sensitivity 
      testing, a provocative dietary trial, and measurement of fecal immunoglobulin E 
      (IgE) in 6 SCWTs affected with PLE or PLN or both. Positive gastroscopic 
      food-sensitivity test reactions were noted in 5 of 6 dogs. Positive reactions 
      were found to milk in 4 dogs, to lamb in 2 dogs, and to wheat and chicken each in 
      1 dog. Adverse reactions to food (diarrhea, vomiting, or pruritus) were detected 
      in all 6 dogs during the provocative dietary trial. Adverse reactions were found 
      to corn in 5 dogs, to tofu in 3 dogs, to cottage cheese in 2 dogs, to milk in 2 
      dogs, to farina cream of wheat in 2 dogs, and to lamb in 2 dogs. Serum albumin 
      concentrations significantly decreased and fecal alpha1-protease inhibitor 
      concentration significantly increased 4 days after the provocative trial when 
      compared with baseline values. Antigen-specific fecal IgE varied throughout the 
      provocative trial, with peak levels following ingestion of test meals. We 
      conclude that food hypersensitivities are present in SCWTs affected with the 
      syndrome of PLE/PLN. Mild inflammatory bowel disease was already established in 
      the 6 SCWTs of this report at the time of study, making it impossible to 
      determine if food allergies were the cause or result of the enteric disease.
FAU - Vaden, S L
AU  - Vaden SL
AD  - Department of Clinical Sciences, North Carolina State University, College of 
      Veterinary Medicine, Raleigh 27606, USA. shelly_vanden@ncsu.edu
FAU - Hammerberg, B
AU  - Hammerberg B
FAU - Davenport, D J
AU  - Davenport DJ
FAU - Orton, S M
AU  - Orton SM
FAU - Trogdon, M M
AU  - Trogdon MM
FAU - Melgarejo, L T
AU  - Melgarejo LT
FAU - VanCamp, S D
AU  - VanCamp SD
FAU - Williams, D A
AU  - Williams DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Dog Diseases/*immunology
MH  - Dogs
MH  - Feces/chemistry
MH  - Female
MH  - Food Hypersensitivity/complications/immunology/*veterinary
MH  - Glomerulonephritis/etiology/immunology/*veterinary
MH  - Immunoglobulin E/analysis
MH  - Inflammatory Bowel Diseases/immunology/*veterinary
MH  - Male
MH  - Protein-Losing Enteropathies/etiology/immunology/*veterinary
MH  - Syndrome
EDAT- 2000/02/11 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/11 09:00
PHST- 2000/02/11 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/11 09:00 [entrez]
AID - 10.1892/0891-6640(2000)014<0060:fhrisc>2.3.co;2 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2000 Jan-Feb;14(1):60-7. doi: 
      10.1892/0891-6640(2000)014<0060:fhrisc>2.3.co;2.