PMID- 10669111
OWN - NLM
STAT- MEDLINE
DCOM- 20000306
LR  - 20061115
IS  - 1023-3830 (Print)
IS  - 1023-3830 (Linking)
VI  - 48
IP  - 12
DP  - 1999 Dec
TI  - The Lps locus: genetic regulation of host responses to bacterial 
      lipopolysaccharide.
PG  - 613-20
AB  - Lipopolysaccharide (LPS), an abundant glycolipid of the outer membrane of 
      gram-negative bacteria, is able to provoke a generalized proinflammatory response 
      in the infected host. Genetic regulation of this trait has been localized to the 
      Lps locus on mouse chromosome 4. Several inbred mouse strains, including C3H/HeJ, 
      C57BL/10ScNCr and C57BL/10ScCr, bear mutations at the Lps locus (Lps(d)) that 
      confer hyporesponsiveness to the immunostimulatory properties of LPS and 
      susceptibility to overwhelming gram-negative bacterial infection. The phenotypic 
      expression of Lps(d) is pleiotropic, affecting several cell types crucial to host 
      defense, including the macrophage. By positional cloning, Toll-like receptor 4 
      (Tlr4), a transmembrane protein with a cytoplasmic domain that bears homology to 
      the Interleukin-1 receptor, has been identified as the gene encoded by Lps. Tlr4 
      is a member of a novel gene family that participates in host defense against 
      microbial infection in plants, invertebrates and mammals. Discovery of the 
      molecular basis of the Lps mutation represents a significant advance in defining 
      the fundamental mechanisms of cellular activation by LPS.
FAU - Qureshi, S T
AU  - Qureshi ST
AD  - Department of Medicine, McGill University, Montreal, Quebec, Canada. 
      mc76@musica.mcgill.ca
FAU - Gros, P
AU  - Gros P
FAU - Malo, D
AU  - Malo D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Ran protein, mouse)
RN  - EC 3.6.5.2 (Monomeric GTP-Binding Proteins)
RN  - EC 3.6.5.2 (ran GTP-Binding Protein)
SB  - IM
MH  - Animals
MH  - Bacteria/*metabolism
MH  - Humans
MH  - Lipopolysaccharides/*toxicity
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Monomeric GTP-Binding Proteins/*genetics
MH  - ran GTP-Binding Protein
RF  - 82
EDAT- 2000/02/11 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/11 09:00
PHST- 2000/02/11 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/11 09:00 [entrez]
AID - 10.1007/s000110050511 [pii]
AID - 10.1007/s000110050511 [doi]
PST - ppublish
SO  - Inflamm Res. 1999 Dec;48(12):613-20. doi: 10.1007/s000110050511.