PMID- 10669694
OWN - NLM
STAT- MEDLINE
DCOM- 20000303
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 117
IP  - 2
DP  - 2000 Feb
TI  - Mediastinal fibrosis is associated with human leukocyte antigen-A2.
PG  - 482-5
AB  - OBJECTIVE: To determine the association between mediastinal fibrosis and human 
      leukocyte antigen (HLA) genes. DESIGN: Case-control study. SETTING: Vanderbilt 
      University Medical Center. SUBJECTS: Nineteen consecutive patients with 
      mediastinal fibrosis who presented to the pulmonary clinic at Vanderbilt 
      University Medical Center from 1987 to 1996. The control subjects were 21,086 
      whites who were cadaveric kidney donors from October 1987 through December 1993. 
      MEASUREMENTS: HLA testing was performed on blood samples from all 19 cases. 
      Information on HLA typing for the control subjects was obtained from the United 
      Network for Organ Sharing. Frequency of HLA class I and II antigens found in the 
      cases was compared with the frequency in the control subjects. RESULTS: The 
      relative risk of mediastinal fibrosis among subjects with the HLA-A2 antigen was 
      3.32 times that of those who lacked this antigen (95% confidence interval, 1.19 
      to 9. 2). CONCLUSION: HLA-A2 was strongly associated with mediastinal fibrosis, 
      suggesting that an abnormal immune response is important in the pathogenesis of 
      this disease. Key words: Histoplasma capsulatum; human leukocyte antigen-A2; 
      mediastinal fibrosis
FAU - Peebles, R S
AU  - Peebles RS
AD  - Center for Lung Research and Department of Medicine, Vanderbilt University School 
      of Medicine, Nashville, TN 37232-2386, USA.
FAU - Carpenter, C T
AU  - Carpenter CT
FAU - Dupont, W D
AU  - Dupont WD
FAU - Loyd, J E
AU  - Loyd JE
LA  - eng
GR  - HL 07123/HL/NHLBI NIH HHS/United States
GR  - HL 48164/HL/NHLBI NIH HHS/United States
GR  - K08 HL 03730/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Fibrosis/diagnosis/genetics/immunology
MH  - Gene Frequency/genetics
MH  - HLA-A2 Antigen/*genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Testing
MH  - Histoplasmosis/diagnosis/genetics/immunology
MH  - Humans
MH  - Male
MH  - Mediastinal Diseases/diagnosis/genetics/*immunology
MH  - Middle Aged
MH  - Risk
EDAT- 2000/02/12 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/12 09:00
PHST- 2000/02/12 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/12 09:00 [entrez]
AID - S0012-3692(15)48641-6 [pii]
AID - 10.1378/chest.117.2.482 [doi]
PST - ppublish
SO  - Chest. 2000 Feb;117(2):482-5. doi: 10.1378/chest.117.2.482.