PMID- 10670823
OWN - NLM
STAT- MEDLINE
DCOM- 20000222
LR  - 20190826
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 124
IP  - 2
DP  - 2000 Jan 15
TI  - Induction by perfluorinated fatty acids with different carbon chain length of 
      peroxisomal beta-oxidation in the liver of rats.
PG  - 119-32
AB  - The potency of the induction of peroxisomal beta-oxidation was compared between 
      perfluorinated fatty acids (PFCAs) with different carbon chain lengths in the 
      liver of male and female rats. In male rats, perfluoroheptanoic acid (PFHA) has 
      little effect, although perfluorooctanoic acid (PFOA), perfluorononanoic acid 
      (PFNA) and perfluorodecanoic acid (PFDA) potentially induced the activity. By 
      contrast, PFHA and PFOA did not induce the activity of peroxisomal beta-oxidation 
      in the liver of female rats while PFNA and PFDA effectively induced the activity. 
      The induction of the activity by these PFCAs was in a dose-dependent manner, and 
      there is a highly significant correlation between the induction and hepatic 
      concentrations of PFCAs in the liver regardless of their carbon chain lengths. 
      These results strongly suggest that the difference in their chemical structure is 
      not the cause of the difference in the potency of the induction. Hepatic 
      concentrations of PFOA and PFNA was markedly higher in male compared with female 
      rats. Castration of male rats reduced the concentration of PFNA in the liver and 
      treatment with testosterone entirely restored the reduction. In contrast to the 
      results obtained from the in vivo experiments, the activity of peroxisomal 
      beta-oxidation was induced by PFDA and PFOA to the same extent in cultured 
      hepatocytes prepared from both male and female rats. These results, taken 
      together, indicate that difference in accumulation between PFCAs in the liver was 
      responsible for the different potency of the induction of peroxisomal 
      beta-oxidation between PFCAs with different carbon chain lengths and between 
      sexes.
FAU - Kudo, N
AU  - Kudo N
AD  - Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan.
FAU - Bandai, N
AU  - Bandai N
FAU - Suzuki, E
AU  - Suzuki E
FAU - Katakura, M
AU  - Katakura M
FAU - Kawashima, Y
AU  - Kawashima Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Caprylates)
RN  - 0 (Decanoic Acids)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 335-76-2 (perfluorodecanoic acid)
RN  - 375-85-9 (perfluoro-n-heptanoic acid)
RN  - 375-95-1 (perfluoro-n-nonanoic acid)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.3.3.6 (Acyl-CoA Oxidase)
SB  - IM
MH  - Acyl-CoA Oxidase
MH  - Animals
MH  - Caprylates/pharmacology
MH  - Cells, Cultured
MH  - Decanoic Acids/pharmacology
MH  - Enzyme Induction/drug effects
MH  - Fatty Acids/chemistry/pharmacokinetics/*pharmacology
MH  - Female
MH  - Fluorocarbons/pharmacology
MH  - Heptanoic Acids/pharmacology
MH  - Hydrocarbons, Fluorinated/chemistry/pharmacokinetics/*pharmacology
MH  - Liver/*drug effects/*metabolism
MH  - Male
MH  - Orchiectomy
MH  - Oxidation-Reduction
MH  - Oxidoreductases/biosynthesis
MH  - Peroxisomes/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Characteristics
MH  - Testosterone/pharmacology
EDAT- 2000/02/12 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/12 09:00
PHST- 2000/02/12 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/12 09:00 [entrez]
AID - S0009-2797(99)00150-7 [pii]
AID - 10.1016/s0009-2797(99)00150-7 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2000 Jan 15;124(2):119-32. doi: 
      10.1016/s0009-2797(99)00150-7.