PMID- 10671223
OWN - NLM
STAT- MEDLINE
DCOM- 20000314
LR  - 20061115
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 30
IP  - 2
DP  - 2000 Feb
TI  - A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T 
      lymphocytes.
PG  - 652-60
AB  - Tumor necrosis factor-alpha (TNF-alpha) can elicit many cellular responses 
      including programmed cell death or apotosis. TNF-alpha-induced apoptosis has been 
      largely attributed to the p60 TNF-R1 receptor. The role of p80 in 
      TNF-alpha-mediated apoptosis is largely unknown. We now present evidence that 
      signaling through p80 switches on the previously dormant apoptotic machinery 
      associated with p60. This effect on p60-associated apoptosis involves the 
      proximal activation of caspases and proceeds in the presence of strong NF-kappaB 
      induction. We evaluated the role of TRAF2 in p80-assisted apoptosis and found 
      that a decrease in TRAF2 protein occurs with p80 but not p60 stimulation. 
      However, the decrease in TRAF2 protein can be dissociated from apoptosis in the 
      presence of a caspase inhibitor. Hence, one means by which p80 TNF-R2 regulates 
      apoptosis is through its ability to amplify internally apoptotic signal 
      transduction from p60 TNF-R1.
FAU - Chan, F K
AU  - Chan FK
AD  - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Bethesda, MD 20892-1892, USA.
FAU - Lenardo, M J
AU  - Lenardo MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antigens, CD/*immunology
MH  - Apoptosis/*immunology
MH  - Humans
MH  - Jurkat Cells
MH  - Receptors, Tumor Necrosis Factor/*immunology
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Signal Transduction/*immunology
MH  - T-Lymphocytes/*immunology/*pathology
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 2000/02/12 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/02/12 09:00
PHST- 2000/02/12 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/02/12 09:00 [entrez]
AID - 10.1002/(SICI)1521-4141(200002)30:02<652::AID-IMMU652>3.0.CO;2-8 [pii]
AID - 10.1002/1521-4141(200002)30:2<652::AID-IMMU652>3.0.CO;2-L [doi]
PST - ppublish
SO  - Eur J Immunol. 2000 Feb;30(2):652-60. doi: 
      10.1002/1521-4141(200002)30:2<652::AID-IMMU652>3.0.CO;2-L.