PMID- 10671893
OWN - NLM
STAT- MEDLINE
DCOM- 20000327
LR  - 20190905
IS  - 1464-4096 (Print)
IS  - 1464-4096 (Linking)
VI  - 85
IP  - 3
DP  - 2000 Feb
TI  - Do experimentally induced ipsilateral testicular torsion, vas deferens 
      obstruction, intra-abdominal testis or venous obstruction damage the 
      contralateral testis through a common mechanism?
PG  - 330-5
AB  - OBJECTIVE: To evaluate if various conditions affecting the ipsilateral testis 
      which also damage the contralateral testis share a common pathway for their 
      effects. MATERIALS AND METHODS: The study comprised five groups of 10 adult rats 
      which underwent surgery to produce (on their left sides); group 1, a sham 
      operation (control); group 2, testicular torsion; group 3, vas deferens 
      obstruction; group 4, an intra-abdominal testis; and group 5, venous obstruction. 
      The ipsilateral and contralateral testes were harvested 4 weeks after surgery. 
      The relative proportions of haploid cells, the mean seminiferous tubular diameter 
      (MSTD), mean testicular biopsy scores (MTBS), and lactate and hypoxanthine levels 
      were determined and compared. RESULTS: The proportions of haploid cells in the 
      ipsilateral and the contralateral testes of groups 2-5 were significantly lower 
      than those of the corresponding testes of the control group. The MSTD and MTBS of 
      the ipsilateral testes in groups 2-5 were also significantly lower than the 
      ipsilateral testes of controls and the contralateral testes within the same 
      groups. While the MSTD and MTBS of the contralateral testes of groups 1 and 5 
      were not significantly different, those of the contralateral testes of groups 2-4 
      were significantly less than that of group 1. The lactic acid and hypoxanthine 
      levels of the ipsilateral and contralateral testes were significantly increased 
      in groups 2 and 3. While only the hypoxanthine level of group 5 increased 
      significantly, both variables were not significantly different between the 
      ipsilateral testes of groups 1 and 4. CONCLUSIONS: These four treatments damaged 
      both the ipsilateral and contralateral testes. As the lactic acid and 
      hypoxanthine levels within the contralateral testis were greater than in the 
      controls, testicular torsion and vas deferens obstruction seem to share a common 
      pathway (which may be a reflex decrease in contralateral testicular blood flow) 
      for their effects on the contralateral testis.
FAU - Andiran, F
AU  - Andiran F
AD  - Departments of Paediatric Surgery, Paediatric Haematology, Biochemistry and 
      Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
FAU - Okur, D H
AU  - Okur DH
FAU - Kilinc, A
AU  - Kilinc A
FAU - Gediko&gmacr;lu, G
AU  - Gediko&gmacr;lu G
FAU - Kilinc, K
AU  - Kilinc K
FAU - Tanyel, F C
AU  - Tanyel FC
LA  - eng
PT  - Journal Article
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Animals
MH  - Constriction, Pathologic/pathology
MH  - Cryptorchidism/pathology
MH  - Flow Cytometry
MH  - Male
MH  - Peripheral Vascular Diseases/complications/pathology
MH  - Rats
MH  - Seminiferous Tubules/pathology
MH  - Spermatic Cord Torsion/*etiology/pathology
MH  - Vas Deferens/*blood supply
MH  - Veins
EDAT- 2000/02/15 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/02/15 09:00
PHST- 2000/02/15 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/15 09:00 [entrez]
AID - bju426 [pii]
AID - 10.1046/j.1464-410x.2000.00426.x [doi]
PST - ppublish
SO  - BJU Int. 2000 Feb;85(3):330-5. doi: 10.1046/j.1464-410x.2000.00426.x.