PMID- 10671994
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20190921
IS  - 0141-9854 (Print)
IS  - 0141-9854 (Linking)
VI  - 21
IP  - 6
DP  - 1999 Dec
TI  - Paediatric myelodysplastic syndrome (MDS) and juvenile chronic myelogenous 
      leukaemia (JCML) detected by cytogenetic and FISH techniques.
PG  - 403-6
AB  - This report presents two rare cases, one of paediatric myelodysplastic syndrome 
      (MDS) and the other juvenile chronic myeloid leukaemia (jCML). In the first case, 
      there were clinical and biological features of MDS-refractory anaemia with excess 
      blasts (RAEB). The bone marrow (BM) karyotype demonstrated a monosomy 7 which was 
      confirmed by fluorescence in situ hybridization (FISH). In addition, FISH 
      analysis showed that an alpha-satellite DNA sequence had been transferred from 
      chromosomes 13/21 to one homologue of chromosomes 22. The BCR-ABL rearrangement 
      was negative. In the second case, at diagnosis, the karyotype was 46,XX. FISH 
      analysis with the simultaneous and individual application of abl and bcr probes 
      for chromosome 9 and 22, respectively, revealed the presence of the BCR-ABL 
      rearrangement in addition to an extra ABL sequence locating chromosome 20. A 
      clone that was BCR-ABL gene rearrangement negative but with an extra ABL DNA 
      sequence on chromsome 20, and another clone that was BCR-ABL gene rearrangement 
      negative were detected by DC-FISH and uni-colour (UC-) FISH analysis. No monosomy 
      7 was detected by conventional cytogenetic or FISH analyses.
FAU - Acar, H
AU  - Acar H
AD  - Department of Genetics and Department of Paediatric Haematology, Medical Faculty, 
      Selcuk University, 42080 Konya-Turkiye.
FAU - Caliskan, U
AU  - Caliskan U
FAU - Cora, T
AU  - Cora T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Lab Haematol
JT  - Clinical and laboratory haematology
JID - 7907061
SB  - IM
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*diagnosis/*genetics
MH  - Male
MH  - Myelodysplastic Syndromes/*diagnosis/*genetics
EDAT- 2000/02/15 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/15 09:00
PHST- 2000/02/15 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/15 09:00 [entrez]
AID - clh249 [pii]
AID - 10.1046/j.1365-2257.1999.00249.x [doi]
PST - ppublish
SO  - Clin Lab Haematol. 1999 Dec;21(6):403-6. doi: 10.1046/j.1365-2257.1999.00249.x.