PMID- 10672313
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 99
IP  - 2
DP  - 2000 Feb
TI  - Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's 
      disease brain.
PG  - 91-5
AB  - A growing amount of evidence indicates that matrix metalloproteinases (MMPs) may 
      play an important role in the pathogenesis of Alzheimer's disease (AD). 
      Stromelysin-1 (MMP-3) plays a central role in activating latent-type MMPs, which 
      are originally secreted as proenzymes. We examined MMP-3 immunoreactivity in the 
      brains of patients who had suffered from Alzheimer's disease and in those of 
      neurologically normal persons. The interstitium between myelinated axons and 
      astrocytes in the white matter of all brain tissues, and senile plaques in the 
      gray matter of the patients with AD were stained with a monoclonal antibody to 
      MMP-3. Comparison of the number of senile plaques stained with the antibody 
      against MMP-3 in the parietal cortex with that in the hippocampus showed that 
      fewer plaques were stained in the hippocampus. The selective distribution of 
      MMP-3 in the human brain suggests that MMP-3 might play an important role in the 
      pathogenesis of AD, especially in the degradation of beta-amyloid protein.
FAU - Yoshiyama, Y
AU  - Yoshiyama Y
AD  - Department of Neurology, School of Medicine, Chiba University, Japan. 
      yoshiyam@mx2.nisiq.net
FAU - Asahina, M
AU  - Asahina M
FAU - Hattori, T
AU  - Hattori T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 0 (Antibodies, Monoclonal)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*enzymology/pathology
MH  - Antibodies, Monoclonal
MH  - Astrocytes/enzymology
MH  - Axons/enzymology
MH  - Brain/*enzymology/pathology
MH  - Female
MH  - Hippocampus/enzymology/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Middle Aged
MH  - Parietal Lobe/enzymology/pathology
MH  - Plaque, Amyloid/enzymology/pathology
MH  - Reference Values
EDAT- 2000/02/15 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/15 09:00
PHST- 2000/02/15 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/15 09:00 [entrez]
AID - 10.1007/pl00007428 [doi]
PST - ppublish
SO  - Acta Neuropathol. 2000 Feb;99(2):91-5. doi: 10.1007/pl00007428.