PMID- 10673399
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20220409
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 267
IP  - 3
DP  - 2000 Jan 27
TI  - Interferon-gamma mediates gene expression of IL-18 binding protein in 
      nonleukocytic cells.
PG  - 960-3
AB  - Interleukin-18 (IL-18) binding protein is a soluble decoy receptor for IL-18 
      which efficiently antagonizes biological functions of IL-18 in vitro and in vivo. 
      Since regulation of IL-18 activity likely contributes to the pathogenesis of 
      inflammatory diseases as well as malignancies, we investigated gene expression of 
      IL-18 binding protein (IL-18BP) in different human cell systems, namely in the 
      keratinocyte cell line HaCaT, in the colon carcinoma cell line DLD-1, and in 
      primary renal mesangial cells. In unstimulated cells only minute amounts of mRNA 
      coding for IL-18 binding protein were detectable. However, in all three cell 
      types gene expression was markedly upregulated by interferon-gamma (IFN-gamma). 
      IL-18 is recognized as a pivotal mediator of IFN-gamma production. Therefore, the 
      present data imply that activity of IL-18 is modulated by a negative feedback 
      mechanism which is mediated by IFN-gamma-induced IL-18 binding protein.
CI  - Copyright 2000 Academic Press.
FAU - Muhl, H
AU  - Muhl H
AD  - Zentrum der Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universitat 
      Frankfurt am Main, Frankfurt am Main, Germany. H.Muehl@em.unifrankfurt.de
FAU - Kampfer, H
AU  - Kampfer H
FAU - Bosmann, M
AU  - Bosmann M
FAU - Frank, S
AU  - Frank S
FAU - Radeke, H
AU  - Radeke H
FAU - Pfeilschifter, J
AU  - Pfeilschifter J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-18)
RN  - 0 (interleukin-18 binding protein)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Cell Line
MH  - Cells, Cultured
MH  - Colonic Neoplasms
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Glomerular Mesangium/cytology/drug effects/physiology
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Interferon-gamma/*pharmacology
MH  - Interleukin-1/pharmacology
MH  - Interleukin-18/genetics
MH  - Keratinocytes
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription, Genetic/drug effects/*physiology
MH  - Tumor Cells, Cultured
EDAT- 2000/02/16 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/16 09:00
PHST- 2000/02/16 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/16 09:00 [entrez]
AID - S0006-291X(99)92064-8 [pii]
AID - 10.1006/bbrc.1999.2064 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Jan 27;267(3):960-3. doi: 
      10.1006/bbrc.1999.2064.