PMID- 10673740
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 14
IP  - 2
DP  - 2000 Feb
TI  - Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia.
PG  - 241-6
AB  - Twenty new cases of acute lymphoblastic leukemia (ALL) with the dicentric 
      chromosome dic(9;20)(p1113;q11) are presented. This chromosomal abnormality is 
      difficult to identify from G-banding alone. It masquerades as monosomy 20 and is 
      only accurately identified by fluorescence in situ hybridization (FISH). Monosomy 
      20 was found in 59/2790 patients with successful karyotypes entered to the 
      Leukaemia Research Fund/UK Cancer Cytogenetics Group Karyotype Database in ALL 
      (LRF/UKCCG Karyotype Database). FISH revealed dic(9;20) in 20/25 cases with 
      available material. Extra copies of chromosome 21 were found in 8 of the 20 
      cases. Patients were 14 females and six males, aged 1-32 years (median 4 years), 
      with leukocyte counts of 2-536 (median 23) x 109/l and immunophenotypes of common 
      or pre-B ALL (17 cases), T-ALL (one case) or unknown (two cases). Four patients 
      relapsed at 2, 22, 28 and 47 months and two died at 49 and 63 months (median 
      follow-up 37 months). FISH studies on the remaining five patients showed one with 
      monosomy 20 and four with other rearrangements of the chromosome. This study has 
      increased the number of reported cases of dic(9;20) from 17 to 37. It has 
      identified dic(9;20) in one case of T-ALL and shows an association of this 
      translocation with trisomy 21.
FAU - Clark, R
AU  - Clark R
AD  - Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype 
      Database in Acute Lymphoblastic Leukaemia, Department of Haematology, Royal Free 
      and University College Medical School, London, UK.
FAU - Byatt, S A
AU  - Byatt SA
FAU - Bennett, C F
AU  - Bennett CF
FAU - Brama, M
AU  - Brama M
FAU - Martineau, M
AU  - Martineau M
FAU - Moorman, A V
AU  - Moorman AV
FAU - Roberts, K
AU  - Roberts K
FAU - Secker-Walker, L M
AU  - Secker-Walker LM
FAU - Richards, S
AU  - Richards S
FAU - Eden, O B
AU  - Eden OB
FAU - Goldstone, A H
AU  - Goldstone AH
FAU - Harrison, C J
AU  - Harrison CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - *Monosomy
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/mortality/pathology
MH  - Survival Analysis
MH  - *Translocation, Genetic
EDAT- 2000/02/16 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/16 09:00
PHST- 2000/02/16 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/16 09:00 [entrez]
AID - 10.1038/sj.leu.2401654 [doi]
PST - ppublish
SO  - Leukemia. 2000 Feb;14(2):241-6. doi: 10.1038/sj.leu.2401654.