PMID- 10674273
OWN - NLM
STAT- MEDLINE
DCOM- 20000301
LR  - 20191103
IS  - 0344-0338 (Print)
IS  - 0344-0338 (Linking)
VI  - 196
IP  - 1
DP  - 2000
TI  - Sustentacular cells in sporadic paraganglioma-like medullary thyroid carcinoma: 
      report of a case with diagnostic and histogenetic considerations.
PG  - 55-9
AB  - Sustentacular cells (SCs) are glial supporting cells of the fetal, adult normal, 
      and neoplastic extra and adrenal human chromaffin cell lineage. SCs have also 
      been identified in some cases of medullary thyroid carcinoma (MTC), raising both 
      diagnostic and histogenetic problems. We report a rare case of a sporadic 
      paraganglioma-like variant of MTC showing numerous S-100 protein and glial 
      fibrillar acid protein (GFAP) positive SCs encircling neoplastic cells in a 
      nesting (Zellballen) pattern similar to that observed in paragangliomas or 
      pheochromocytomas. Although stromal amyloid deposits were only focally detected, 
      diagnosis was immunohistochemically confirmed by immunoreactivity of the 
      neoplastic cells for cytokeratin, CEA, calcitonin, chromogranin A, 
      neuron-specific-enolase, and synapthopysin. As for the histogenesis of SCs, if we 
      assume that MTC is a neural crest-derived tumor, it is likely that these cells 
      reflect the ability of the common precursor cell to differentiate towards a 
      sustentacular-type glial cell lineage in addition to the typical neuroendocrine 
      one. This viewpoint is supported by the evidence that rare cases of MTC may 
      contain neoplastic or supporting cells showing a multidirectional differentiation 
      (usually neuroendocrine and melanocytic) that recapitulates the different cell 
      lineages arising from the developing neural crests.
FAU - Magro, G
AU  - Magro G
AD  - Institute of Anatomical Pathology, University of Catania, Italy.
FAU - Grasso, S
AU  - Grasso S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Carcinoma, Medullary/chemistry/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Middle Aged
MH  - Neuroglia/chemistry/*pathology
MH  - Paraganglioma/chemistry/*pathology
MH  - S100 Proteins/analysis
MH  - Thyroid Neoplasms/chemistry/*pathology
EDAT- 2000/02/16 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/16 09:00
PHST- 2000/02/16 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/16 09:00 [entrez]
AID - 10.1016/s0344-0338(00)80022-9 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2000;196(1):55-9. doi: 10.1016/s0344-0338(00)80022-9.