PMID- 10676427
OWN - NLM
STAT- MEDLINE
DCOM- 20000301
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 895
DP  - 1999
TI  - Reducing uncertainty in the derivation and application of health guidance values 
      in public health practice. Dioxin as a case study.
PG  - 348-64
AB  - We were requested by the U.S. Environmental Protection Agency (EPA) to clarify 
      the relationships among the minimal risk level (MRL), action level, and 
      environmental media evaluation guide (EMEG) for dioxin established by the Agency 
      for Toxic Substances and Disease Registry (ATSDR). In response we developed a 
      document entitled "Dioxin and Dioxin-Like Compounds in Soil, Part I: ATSDR 
      Interim Policy Guideline"; and a supporting document entitled "Dioxin and 
      Dioxin-Like Compounds in Soil, Part II: Technical Support Document". In these 
      documents, we evaluated the key assumptions underlying the development and use of 
      the ATSDR action level, MRL, and EMEG for dioxin. We described the chronology of 
      events outlining these different health guidance values for dioxin and identified 
      the areas of uncertainty surrounding these values. Four scientific assumptions 
      were found to have had a great impact on this process; these were: (1) the 
      specific uncertainty factors used, (2) the toxicity equivalent (TEQ) approach, 
      (3) the fractional exposure from different pathways, and (4) the use of body 
      burdens in the absence of exposure data. This information was subsequently used 
      to develop a framework for reducing the uncertainties in public health risk 
      assessment associated with exposure to other chemical contaminants in the 
      environment. Within this framework are a number of future directions for reducing 
      uncertainty, including physiologically based pharmacokinetic modeling (PBPK), 
      benchmark dose modeling (BMD), functional toxicology, and the assessment of 
      chemical mixture interactions.
FAU - De Rosa, C T
AU  - De Rosa CT
AD  - Agency for Toxic Substances and Disease Registry Public Health Service, U.S. 
      Department of Health and Human Services, Atlanta, Georgia 30333, USA. 
      cyd0@cdc.com
FAU - Pohl, H R
AU  - Pohl HR
FAU - Hansen, H
AU  - Hansen H
FAU - Leonard, R C
AU  - Leonard RC
FAU - Holler, J
AU  - Holler J
FAU - Jones, D
AU  - Jones D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - *Benchmarking
MH  - Dioxins/*adverse effects/standards
MH  - Environmental Health
MH  - Environmental Pollutants/*adverse effects/standards
MH  - Humans
MH  - Pharmacokinetics
MH  - *Policy Making
MH  - *Public Health
MH  - Public Policy
MH  - Reference Values
MH  - Risk Assessment
MH  - Toxicity Tests
MH  - United States
EDAT- 2000/02/17 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/17 09:00
PHST- 2000/02/17 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/17 09:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb08095.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999;895:348-64. doi: 10.1111/j.1749-6632.1999.tb08095.x.