PMID- 10676910
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20191103
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 37
IP  - 1
DP  - 2000 Jan
TI  - Alternative-donor hematopoietic stem-cell transplantation for severe aplastic 
      anemia.
PG  - 43-55
AB  - Bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched 
      sibling is the treatment of choice in children and young adults with severe 
      aplastic anemia (SAA). However, because only 30% of patients have a suitable 
      donor, more aggressive nontransplant immunosuppressive regimens have been used, 
      with reasonable results. The use of mismatched family member and unrelated 
      donors, initially fraught with problems of nonengraftment and severe 
      graft-versus-host disease (GVHD), has improved markedly over the past 10 years. 
      The establishment of donor registries, more precise HLA typing methods, and 
      better supportive care are significant factors in the improved outcomes. The 
      challenge for the future is to assemble the optimal combination of donor 
      selection, conditioning regimen, and GVHD prophylaxis to enhance disease-free 
      survival. These better outcomes should encourage the treating physician to 
      consider stem-cell transplant at an earlier stage of disease.
FAU - Margolis, D A
AU  - Margolis DA
AD  - Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA.
FAU - Casper, J T
AU  - Casper JT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Anemia, Aplastic/*therapy
MH  - Bone Marrow Transplantation
MH  - Fetal Blood
MH  - Graft vs Host Disease/prevention & control
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Tissue Donors
MH  - Transplantation Conditioning
RF  - 77
EDAT- 2000/02/17 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/17 09:00
PHST- 2000/02/17 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/17 09:00 [entrez]
AID - S0037196300000056 [pii]
AID - 10.1016/s0037-1963(00)90029-5 [doi]
PST - ppublish
SO  - Semin Hematol. 2000 Jan;37(1):43-55. doi: 10.1016/s0037-1963(00)90029-5.