PMID- 10677035
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 24
IP  - 1
DP  - 1999 Sep
TI  - Identification of maxillary factor, a maxillary process-derived chemoattractant 
      for developing trigeminal sensory axons.
PG  - 165-78
AB  - Trigeminal sensory axons project to several epithelial targets, including those 
      of the maxillary and mandibular processes. Previous studies identified a 
      chemoattractant activity, termed Maxillary Factor, secreted by these processes, 
      which can attract developing trigeminal axons in vitro. We report that Maxillary 
      Factor activity is composed of two neurotrophins, neurotrophin-3 (NT-3) and 
      Brain-Derived Neurotrophic Factor (BDNF), which are produced by both target 
      epithelium and pathway mesenchyme and which are therefore more likely to have a 
      trophic effect on the neurons or their axons than to provide directional 
      information, at least at initial stages of trigeminal axon growth. Consistent 
      with this, the initial trajectories of trigeminal sensory axons are largely or 
      completely normal in mice deficient in both BDNF and NT-3, indicating that other 
      cues must be sufficient for the initial stages of trigeminal axon guidance.
FAU - O'Connor, R
AU  - O'Connor R
AD  - Howard Hughes Medical Institute, Department of Anatomy, University of California, 
      San Francisco 94143, USA.
FAU - Tessier-Lavigne, M
AU  - Tessier-Lavigne M
LA  - eng
GR  - F32-NS10300/NS/NINDS NIH HHS/United States
GR  - P01-DEO8973/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Neuron. 1999 Sep;24(1):1-2. PMID: 10677019
MH  - Animals
MH  - Axons/*physiology
MH  - Brain-Derived Neurotrophic Factor/*analysis/genetics/physiology
MH  - *Chemotactic Factors
MH  - Coculture Techniques
MH  - Epithelium/chemistry
MH  - Gene Expression
MH  - Gestational Age
MH  - Immunohistochemistry
MH  - Maxilla/chemistry/*embryology/innervation
MH  - Maxillary Nerve/embryology
MH  - Mesoderm/chemistry
MH  - Mice
MH  - Mice, Knockout
MH  - Neurotrophin 3/*analysis/genetics/physiology
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Trigeminal Ganglion/embryology
MH  - Trigeminal Nerve/*embryology/ultrastructure
EDAT- 2000/02/17 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/17 09:00
PHST- 2000/02/17 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/17 09:00 [entrez]
AID - S0896-6273(00)80830-2 [pii]
AID - 10.1016/s0896-6273(00)80830-2 [doi]
PST - ppublish
SO  - Neuron. 1999 Sep;24(1):165-78. doi: 10.1016/s0896-6273(00)80830-2.