PMID- 10677310
OWN - NLM
STAT- MEDLINE
DCOM- 20000330
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 66
IP  - 2
DP  - 2000 Feb
TI  - Fine localization of a major disease-susceptibility locus for diffuse 
      panbronchiolitis.
PG  - 501-7
AB  - Diffuse panbronchiolitis affecting East Asians is strongly associated with the 
      class I human leukocyte antigen (HLA) alleles. Recent observations suggest that a 
      major disease-susceptibility gene may be located between the HLA-B and HLA-A loci 
      in the class I region of the major histocompatibility complex on chromosome 6. To 
      test this possibility, we analyzed 14 polymorphic markers in 92 Japanese patients 
      and 93 healthy controls. Of these, seven marker alleles, including HLA-B54 and 
      HLA-A11, were significantly associated with the disease. Maximum-likelihood 
      haplotype analysis and subsequent direct determination of individual haplotypes 
      identified a group of disease-associated haplotypes, one of which contained all 
      seven disease-associated marker alleles. Another haplotype, containing 
      HLA-B*5504, was also associated with the disease. All these haplotypes seem to 
      have diverged from a common ancestral haplotype in East Asians and share a 
      specific segment containing three consecutive markers between the S and TFIIH 
      loci in the class I region. Furthermore, one of the markers within the candidate 
      region showed the highest delta value, indicating the strongest association. Of 
      20 Korean patients with diffuse panbronchiolitis, 17 also shared the combination 
      of the disease-associated marker alleles within the candidate region. These 
      results indicate that an HLA-associated major susceptibility gene for diffuse 
      panbronchiolitis is probably located within the 200 kb in the class I region 300 
      kb telomeric of the HLA-B locus on the chromosome 6p21.3.
FAU - Keicho, N
AU  - Keicho N
AD  - Department of Respiratory Medicine, Graduate School of Medicine, University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. 
      KEICHO-3IM@h.u-tokyo.ac.jp.
FAU - Ohashi, J
AU  - Ohashi J
FAU - Tamiya, G
AU  - Tamiya G
FAU - Nakata, K
AU  - Nakata K
FAU - Taguchi, Y
AU  - Taguchi Y
FAU - Azuma, A
AU  - Azuma A
FAU - Ohishi, N
AU  - Ohishi N
FAU - Emi, M
AU  - Emi M
FAU - Park, M H
AU  - Park MH
FAU - Inoko, H
AU  - Inoko H
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Kudoh, S
AU  - Kudoh S
LA  - eng
SI  - GENBANK/AB023050
SI  - GENBANK/AB032121
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Transcription Factors)
RN  - 0 (Transcription Factors, TFII)
RN  - 148710-81-0 (Transcription Factor TFIIH)
SB  - IM
MH  - Alleles
MH  - Bronchiolitis/*genetics
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Linkage/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Japan
MH  - Korea
MH  - Likelihood Functions
MH  - Male
MH  - Microsatellite Repeats/genetics
MH  - Molecular Sequence Data
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Transcription Factor TFIIH
MH  - Transcription Factors/genetics
MH  - *Transcription Factors, TFII
PMC - PMC1288103
EDAT- 2000/03/21 09:00
MHDA- 2000/04/01 09:00
PMCR- 2000/08/01
CRDT- 2000/03/21 09:00
PHST- 2000/03/21 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/21 09:00 [entrez]
PHST- 2000/08/01 00:00 [pmc-release]
AID - S0002-9297(07)63424-7 [pii]
AID - 991299 [pii]
AID - 10.1086/302786 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2000 Feb;66(2):501-7. doi: 10.1086/302786.