PMID- 10678555
OWN - NLM
STAT- MEDLINE
DCOM- 20000313
LR  - 20221207
IS  - 0368-2811 (Print)
IS  - 0368-2811 (Linking)
VI  - 29
IP  - 11
DP  - 1999 Nov
TI  - Frequency of HLA-A alleles in Japanese patients with head and neck cancer.
PG  - 535-40
AB  - BACKGROUND: Association between certain human leukocyte antigen (HLA) types such 
      as HLA-A1 and -A3 and squamous cell carcinoma of the head and neck (SCCHN) has 
      been demonstrated in the Caucasian population. HLA typings in these studies were 
      performed by conventional serological methods. However, recent comparison studies 
      between serological and molecular typings have revealed that the former are often 
      inaccurate. METHODS: The frequency of HLA-A alleles in 100 Japanese patients with 
      SCCHN and 100 control subjects was determined by the polymerase chain reaction, 
      with primers specific for the HLA-A locus, in combination with dot-blot 
      hybridization with 31 sequence-specific oligonucleotides. RESULTS: The 
      frequencies of HLA-A*2602 and HLA-A*3303 were higher and those of HLA-A*2603 and 
      HLA-A*3101 were lower in the patients with SCCHN than in healthy controls, but 
      these differences were not statistically significant. In the 39 male patients 
      with laryngeal carcinoma, the most common malignancies in Japanese patients with 
      SCCHN, the frequency of HLA-A*2402 was significantly lower than that in the 80 
      male controls; however, after correction of the P value, statistical significance 
      was not confirmed. In oral carcinoma patients, the frequency of HLA-A*2402 was 
      significantly higher than that in healthy controls. CONCLUSIONS: These results 
      suggest that the contribution of certain HLA-A alleles to susceptibility to SCCHN 
      may differ between sites in the head and neck regions, despite these cancers 
      being of an identical histological type, and that HLA-A*2402 may influence the 
      development of oral carcinoma in Japanese patients.
FAU - Eura, M
AU  - Eura M
AD  - Department of Otolaryngology, Kumamoto University School of Medicine, Japan. 
      eura@gpo.kumamoto-u.ac.jp
FAU - Katsura, F
AU  - Katsura F
FAU - Oiso, M
AU  - Oiso M
FAU - Obata, A
AU  - Obata A
FAU - Nakano, K
AU  - Nakano K
FAU - Masuyama, K
AU  - Masuyama K
FAU - Ishikawa, T
AU  - Ishikawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Asian People
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - Head and Neck Neoplasms/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
EDAT- 2000/03/18 00:00
MHDA- 2000/03/18 00:01
CRDT- 2000/03/18 00:00
PHST- 2000/03/18 00:00 [pubmed]
PHST- 2000/03/18 00:01 [medline]
PHST- 2000/03/18 00:00 [entrez]
AID - 10.1093/jjco/29.11.535 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 1999 Nov;29(11):535-40. doi: 10.1093/jjco/29.11.535.