PMID- 10678634
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20220330
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 15
IP  - 1
DP  - 2000 Jan
TI  - Clinically "small" effects of air pollution on FVC have a large public health 
      impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - 
      team.
PG  - 131-6
AB  - Epidemiological studies have repeatedly established adverse health effects due to 
      long-term exposure to ambient air pollution. The Swiss Study on Air Pollution and 
      Lung Disease in Adults (SAPALDIA) published a -3.14% decrease in forced vital 
      capacity (FVC) per 10 microg x m(-3) increment in particulate matter (particles 
      with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)). Compared to the 
      within-subject variability of FVC, the effect may be considered small. This 
      individual (or clinical) perspective is, however, misleading. The purpose of this 
      study was to demonstrate the public health relevance of apparently "small" 
      effects, using the impact of PM10 on FVC as an example. The scenario compares a 
      population A, exposed to an annual mean PM10 of 20 microg x m(-3), with a 
      population B exposed to 30 microg x m(-3) mean PM10. A shift of -3.14% in the 
      population distribution of FVC increases the number of subjects in the lower tail 
      of the distribution. In population B a relative increase was expected of 47% 
      (16-91%) in the prevalence of "FVC <80% predicted", (i.e., from 5.17 to 7.59% and 
      5.88 to 8.65% among males and females, respectively). The relative increase in 
      the prevalence of "FVC <70% predicted" (approximately 1% of population) was 63% 
      (30-98%, males) and 57% (21-86%, females). An epidemiological estimate of a 
      change in the mean value of the population distribution should not be 
      misinterpreted as an effect on the individual level. However, the impact of a 10 
      microg x m(-3) increase in particles with a 50% cut-off aerodynamic diameter of 
      10 microm (PM10) on the number of subjects with a clinically relevant reduction 
      in lung function is quantitatively important.
FAU - Kunzli, N
AU  - Kunzli N
AD  - Institute for Social and Preventive Medicine, University Basel, Switzerland.
FAU - Ackermann-Liebrich, U
AU  - Ackermann-Liebrich U
FAU - Brandli, O
AU  - Brandli O
FAU - Tschopp, J M
AU  - Tschopp JM
FAU - Schindler, C
AU  - Schindler C
FAU - Leuenberger, P
AU  - Leuenberger P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
MH  - Adult
MH  - Air Pollution/*adverse effects
MH  - Asthma/etiology
MH  - Environmental Monitoring
MH  - Female
MH  - Humans
MH  - Male
MH  - Maximum Allowable Concentration
MH  - Particle Size
MH  - *Public Health
MH  - Vital Capacity/*drug effects
EDAT- 2000/03/04 00:00
MHDA- 2000/03/04 00:01
CRDT- 2000/03/04 00:00
PHST- 2000/03/04 00:00 [pubmed]
PHST- 2000/03/04 00:01 [medline]
PHST- 2000/03/04 00:00 [entrez]
AID - 10.1183/09031936.00.15113100 [doi]
PST - ppublish
SO  - Eur Respir J. 2000 Jan;15(1):131-6. doi: 10.1183/09031936.00.15113100.