PMID- 10679411
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20220408
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 12
IP  - 1
DP  - 2000 Feb
TI  - Tlr4: central component of the sole mammalian LPS sensor.
PG  - 20-6
AB  - Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). 
      Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 
      (Tlr4), which functions as the transmembrane component of the LPS receptor 
      complex, an unduplicated pathway for the detection of endotoxin. The structurally 
      related protein Tlr2 makes no contribution to LPS signal transduction.
FAU - Beutler, B
AU  - Beutler B
AD  - Department of Internal Medicine, Howard Hughes Medical Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA. 
      beutler@howie.swmed.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Tl protein, Drosophila)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Alleles
MH  - *Drosophila Proteins
MH  - Genes, Dominant
MH  - Genes, Recessive
MH  - Insect Proteins/genetics
MH  - Lipopolysaccharide Receptors/genetics/*metabolism
MH  - Lipopolysaccharides/*immunology
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Models, Immunological
MH  - Receptors, Cell Surface/genetics/*metabolism
MH  - Signal Transduction
MH  - Toll-Like Receptor 2
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
RF  - 50
EDAT- 2000/02/19 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - S0952-7915(99)00046-1 [pii]
AID - 10.1016/s0952-7915(99)00046-1 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2000 Feb;12(1):20-6. doi: 10.1016/s0952-7915(99)00046-1.