PMID- 10679425
OWN - NLM
STAT- MEDLINE
DCOM- 20000418
LR  - 20191103
IS  - 1369-5274 (Print)
IS  - 1369-5274 (Linking)
VI  - 3
IP  - 1
DP  - 2000 Feb
TI  - Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity.
PG  - 23-8
AB  - Positional cloning work and subsequent biochemical analyses have revealed that 
      Toll-like receptor 4 (Tlr4) transduces the lipopolysaccharide (LPS) signal, 
      alerting the host to infection by Gram-negative bacteria. Moreover, it appears 
      that the LPS sensing pathway is a solitary one: disruption of Tlr4 causes 
      complete unresponsiveness to LPS. As several Tlr family members exist in 
      vertebrates, it appears likely that the innate immune system defends the host by 
      recognizing a small number of structurally conserved molecules that distinguish 
      the microbial world from tissues of the host.
FAU - Beutler, B
AU  - Beutler B
AD  - Howard Hughes Medical institute, University of Texas, Southwestern Medical 
      Center, Dallas, 75235-9050 TX, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Microbiol
JT  - Current opinion in microbiology
JID - 9815056
RN  - 0 (Drosophila Proteins)
RN  - 0 (Endotoxins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptor 5)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (tehao protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Drosophila/immunology
MH  - *Drosophila Proteins
MH  - Endotoxins/chemistry/metabolism
MH  - Gram-Negative Bacteria/*immunology/metabolism
MH  - Gram-Negative Bacterial Infections/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Lipopolysaccharides/*metabolism
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Receptors, Cell Surface/genetics/*metabolism
MH  - Signal Transduction
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptor 5
MH  - Toll-Like Receptors
RF  - 48
EDAT- 2000/02/19 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - S1369-5274(99)00046-6 [pii]
AID - 10.1016/s1369-5274(99)00046-6 [doi]
PST - ppublish
SO  - Curr Opin Microbiol. 2000 Feb;3(1):23-8. doi: 10.1016/s1369-5274(99)00046-6.