PMID- 10679918
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20071115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 27
IP  - 3
DP  - 2000 Mar
TI  - t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share 
      similarities with B-cell chronic lymphocytic leukemia.
PG  - 285-94
AB  - Until now, few data on additional chromosomal aberrations in t(11;14)-positive 
      mantle cell lymphomas (MCLs) have been published. We analyzed 39 
      t(11;14)-positive MCLs by either comparative genomic hybridization (CGH; n = 8), 
      fluorescence in situ hybridization (FISH) with a set of DNA probes detecting the 
      most frequent aberrations in B-cell neoplasms (n = 12), or both techniques (n = 
      19). The t(11;14) was present in all cases. In 37 of 39 cases, chromosomal 
      imbalances were found. In 27 cases, complex karyotypes, i.e., >/= 3 aberrations, 
      were identified. The most frequent aberrations were losses of 13q14-21 or 
      13q32-34 (27 cases), 9p21 (16 cases), and 11q22-23 (12 cases) and gains of 
      3q26-29 (19 cases), 8q22-24 (11 cases), and 18q21-22 (9 cases). In 26% of cases 
      (7 of 27) analyzed by CGH, a total of 10 high-level DNA amplifications were 
      identified. Although in comparison with B-cell chronic lymphopcytic leukemia 
      (B-CLL) MCL is characterized by a much higher complexity of chromosomal 
      aberrations, there are striking similarities: 13q14 deletions were identified in 
      more than 50% of both MCL and B-CLL cases. In contrast, in our CGH database 
      containing 293 B-cell lymphomas, this aberration was found in only 11% of other 
      nodal lymphomas. Even more strikingly, 11q deletions, which are present in 20%-30 
      % of MCL and B-CLL, were found very rarely in other nodal B-cell lymphomas (CGH: 
      1 of 208 cases; FISH: 1 of 69 cases). These data show that MCL is characterized 
      by specific secondary aberrations and that there may be similarities in the 
      pathogenesis of MCL and B-CLL. Genes Chromosomes Cancer 27:285-294, 2000.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Bentz, M
AU  - Bentz M
AD  - Abt. Innere Medizin III der Universitat Ulm, Ulm, Germany.
FAU - Plesch, A
AU  - Plesch A
FAU - Bullinger, L
AU  - Bullinger L
FAU - Stilgenbauer, S
AU  - Stilgenbauer S
FAU - Ott, G
AU  - Ott G
FAU - Muller-Hermelink, H K
AU  - Muller-Hermelink HK
FAU - Baudis, M
AU  - Baudis M
FAU - Barth, T F
AU  - Barth TF
FAU - Moller, P
AU  - Moller P
FAU - Lichter, P
AU  - Lichter P
FAU - Dohner, H
AU  - Dohner H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Female
MH  - Gene Amplification
MH  - Genes, bcl-2/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase/genetics
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/pathology
MH  - Lymphoma, Mantle-Cell/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - Translocation, Genetic/*genetics
EDAT- 2000/02/19 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - 10.1002/(SICI)1098-2264(200003)27:3<285::AID-GCC9>3.0.CO;2-M [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2000 Mar;27(3):285-94.