PMID- 10680558
OWN - NLM
STAT- MEDLINE
DCOM- 20000314
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 111
IP  - 2
DP  - 2000 Feb
TI  - The effect of interstimulus intervals and between-block rests on the auditory 
      evoked potential and magnetic field: is the auditory P50 in humans an overlapping 
      potential?
PG  - 237-45
AB  - OBJECTIVE: The human auditory P50 may consist of overlapping potentials. To test 
      this hypothesis, we manipulated interstimulus intervals (ISIs) and between-block 
      rests, and recorded the P50, P50m, N100 and the N100m simultaneously. METHODS: 
      Subjects were 12 right-handed healthy adults. Four conditions included: (1) 1.5 
      s/rest, (2) 1.5 s/successive, (3) 0.5 s/rest, and (4) 0.5 s/successive. Auditory 
      stimuli were presented a total of 880 times for each condition. Auditory evoked 
      potentials and magnetic fields were recorded. We examined the P50, N100, P50m, 
      N100m and dipoles of the P50m and the N100m. RESULTS: There was no significant 
      effect of the ISI on the P50 amplitudes, but the P50m amplitudes in the 0.5 s ISI 
      conditions were significantly smaller than those in the 1.5 s ISI conditions. The 
      N100 and the N100m amplitudes in the 0.5 s ISI conditions were significantly 
      smaller than those in the 1.5 s ISI conditions. The N100 and the N100m amplitudes 
      in the resting conditions were significantly larger than those in the successive 
      conditions. The P50m dipoles were slightly deeper and more anterior than those of 
      the N100m in primary auditory cortex. CONCLUSIONS: Central structures other than 
      supratemporal cortex contribute to the P50 and that the P50 in humans represents 
      overlapping potentials.
FAU - Onitsuka, T
AU  - Onitsuka T
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Ninomiya, H
AU  - Ninomiya H
FAU - Sato, E
AU  - Sato E
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Tashiro, N
AU  - Tashiro N
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - *Magnetics
MH  - Male
MH  - Reaction Time/physiology
EDAT- 2000/02/19 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - S1388-2457(99)00241-2 [pii]
AID - 10.1016/s1388-2457(99)00241-2 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2000 Feb;111(2):237-45. doi: 10.1016/s1388-2457(99)00241-2.