PMID- 10680599
OWN - NLM
STAT- MEDLINE
DCOM- 20000225
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 148
IP  - 1
DP  - 2000 Jan 1
TI  - Involvement of retinoblastoma protein in p27Kip1-induced apoptosis.
PG  - 105-10
AB  - p27Kip1, a cyclin-dependent kinase (CDK) inhibitor, plays a critical role in cell 
      cycle regulation. Expression of p27Kip1 is shown to increase during apoptosis in 
      mammalian cells. Here, to directly address the role of p27Kip1 in apoptosis, 
      p27Kip1 is overexpressed in human SK-Hep1 hepatoma cells. This leads to apoptotic 
      cell death and this reduces protein, but not mRNA, levels of the retinoblastoma 
      (Rb). Consistently, accumulation of Rb protein blocks p27Kip1-mediated apoptosis. 
      These studies demonstrate an involvement of Rb in the apoptotic cell death which 
      is induced by overexpression of p27Kip1.
FAU - Oh, S
AU  - Oh S
AD  - Institute for Molecular Biology and Genetics, Department of Microbiology, Seoul 
      National University, South Korea.
FAU - Kim, T K
AU  - Kim TK
FAU - Hwang, D S
AU  - Hwang DS
FAU - Yim, J
AU  - Yim J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - *Apoptosis
MH  - Blotting, Western
MH  - *Cell Cycle Proteins
MH  - Cyclin-Dependent Kinase Inhibitor p27
MH  - Cyclin-Dependent Kinases/antagonists & inhibitors
MH  - DNA/analysis/genetics
MH  - DNA Fragmentation
MH  - Down-Regulation
MH  - Gene Expression
MH  - Humans
MH  - Liver Neoplasms/genetics/metabolism/pathology
MH  - Microtubule-Associated Proteins/*antagonists & inhibitors/genetics/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Retinoblastoma Protein/genetics/*metabolism
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Protein p53/genetics/metabolism
MH  - *Tumor Suppressor Proteins
EDAT- 2000/02/19 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - S0304-3835(99)00319-5 [pii]
AID - 10.1016/s0304-3835(99)00319-5 [doi]
PST - ppublish
SO  - Cancer Lett. 2000 Jan 1;148(1):105-10. doi: 10.1016/s0304-3835(99)00319-5.