PMID- 10680740
OWN - NLM
STAT- MEDLINE
DCOM- 20000314
LR  - 20191103
IS  - 1386-6532 (Print)
IS  - 1386-6532 (Linking)
VI  - 16
IP  - 1
DP  - 2000 Feb
TI  - Seroprevalence of viral childhood infections in Eritrea.
PG  - 49-54
AB  - BACKGROUND: The seroprevalence of viral childhood infections in Africa has not 
      been thoroughly investigated. The relatively recently discovered human parvovirus 
      B19 (B19) and human herpesvirus 6 (HHV-6) have received particularly little 
      attention. OBJECTIVE: To investigate the seroprevalence of viral childhood 
      infections in different Eritrean populations and to define groups at high risk 
      for infection. STUDY DESIGN: Five population groups in Eritrea have been examined 
      to define the prevalence of specific antibodies to several childhood viruses. The 
      study population of more than 400 persons consisted of children, pregnant women, 
      female sex workers and members of a secluded tribe called Rashaida. RESULTS: All 
      groups showed a high prevalence of antibodies to measles and HHV-6 (> 85%). For 
      rubella, the seroprevalence was very high in all adult groups (93-99%) except the 
      Rashaida group (71%). The mumps prevalence was surprisingly low in the Rashaida 
      group (29%) compared to 46-85% in the other adults. Late encounter of mumps and 
      rubella was also observed among the Rashaidas. The pattern of antibodies to B19 
      showed a higher seroprevalence in all groups (56-91%) compared to what has been 
      reported from the western world. CONCLUSION: The findings represent what might be 
      expected in an unvaccinated population. The exception was the Rashaidas, which 
      had low seroprevalences and late encounter of mumps and rubella. This is of 
      importance because it makes this tribe vulnerable to these infections, which are 
      associated with complications when acquired in adult age. Also noteworthy is the 
      high frequency of antibodies to HHV-6 and particularly B19 in all groups, 
      indicative of an early encounter of both these viruses.
FAU - Tolfvenstam, T
AU  - Tolfvenstam T
AD  - Department of Clinical Virology, Karolinska Institutet, Huddinge University 
      Hospital, Stockholm, Sweden. thomas.tolfvenstam@impi.ki.se
FAU - Enbom, M
AU  - Enbom M
FAU - Ghebrekidan, H
AU  - Ghebrekidan H
FAU - Ruden, U
AU  - Ruden U
FAU - Linde, A
AU  - Linde A
FAU - Grandien, M
AU  - Grandien M
FAU - Wahren, B
AU  - Wahren B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Eritrea/epidemiology
MH  - Female
MH  - Herpesviridae Infections/epidemiology/virology
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Measles/epidemiology/virology
MH  - Mumps/epidemiology/virology
MH  - Parvoviridae Infections/epidemiology/virology
MH  - Parvovirus B19, Human/immunology
MH  - Pregnancy
MH  - Rubella/epidemiology/virology
MH  - Seroepidemiologic Studies
MH  - Virus Diseases/*epidemiology/virology
EDAT- 2000/02/19 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
AID - S1386-6532(99)00070-0 [pii]
AID - 10.1016/s1386-6532(99)00070-0 [doi]
PST - ppublish
SO  - J Clin Virol. 2000 Feb;16(1):49-54. doi: 10.1016/s1386-6532(99)00070-0.