PMID- 10681461
OWN - NLM
STAT- MEDLINE
DCOM- 20000411
LR  - 20220309
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 97
IP  - 5
DP  - 2000 Feb 29
TI  - Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory 
      neurons in neurotrophin-4 mutant mice.
PG  - 2297-302
AB  - Peripheral ganglion neurons confer sensory information including touch, pain, 
      temperature, and proprioception. Sensory modality is linked to specific 
      neurotrophin (NTF) requirements. NT-3 supports survival of neurons that 
      differentiate primarily into proprioceptors whereas nerve growth factor and 
      brain-derived neurotrophic factor (BDNF) support subpopulations that transmit 
      nociception and mechanoreception, respectively. We examined sensory neurons of 
      gene-targeted mouse mutants at the NT-4, BDNF, NT-3, and TrkA loci. We show that 
      NT-4 functions early in gangliogenesis, upstream of BDNF. In the absence of NT-4 
      function, BDNF-dependent, TrkB-expressing neurons fail to appear. The results are 
      consistent with the model that precursor cells intended to become BDNF-dependent 
      mechanoreceptors instead differentiate into NT-3-dependent proprioceptive 
      neurons.
FAU - Liebl, D J
AU  - Liebl DJ
AD  - Center for Developmental Biology, University of Texas Southwestern Medical 
      Center, 6000 Harry Hines Boulevard, Dallas, TX 75235-9133, USA.
FAU - Klesse, L J
AU  - Klesse LJ
FAU - Tessarollo, L
AU  - Tessarollo L
FAU - Wohlman, T
AU  - Wohlman T
FAU - Parada, L F
AU  - Parada LF
LA  - eng
GR  - R37 NS033199/NS/NINDS NIH HHS/United States
GR  - T32 GM008203/GM/NIGMS NIH HHS/United States
GR  - R01 NS 33199/NS/NINDS NIH HHS/United States
GR  - T32GM08203/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Count
MH  - Ganglia, Spinal/cytology
MH  - Gene Expression
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Nerve Growth Factors/genetics/*physiology
MH  - Neural Crest/*cytology
MH  - Neurons, Afferent/*cytology
MH  - Receptor, trkB/biosynthesis
PMC - PMC15795
EDAT- 2000/02/19 09:00
MHDA- 2000/04/15 09:00
PMCR- 2000/08/29
CRDT- 2000/02/19 09:00
PHST- 2000/02/19 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 2000/02/19 09:00 [entrez]
PHST- 2000/08/29 00:00 [pmc-release]
AID - 040562597 [pii]
AID - 5625 [pii]
AID - 10.1073/pnas.040562597 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302. doi: 
      10.1073/pnas.040562597.