PMID- 10681606
OWN - NLM
STAT- MEDLINE
DCOM- 20000412
LR  - 20171101
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 200
IP  - 1
DP  - 2000
TI  - Clinical, histological and immunopathological features of 58 patients with 
      subacute cutaneous lupus erythematosus. A review by the Italian group of 
      immunodermatology.
PG  - 6-10
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of 
      cutaneous lupus erythematosus clinically characterized by psoriasiform and/or 
      annular lesions and by a mild or absent systemic involvement. OBJECTIVE: The 
      Italian Group of Immunodermatology of the Italian Society of Dermatology and 
      Venereology reviewed the cases of SCLE seen in 10 years (1987-1996). PATIENTS: 
      Forty-six women and 12 men have been retrospectively studied, 42% had annular 
      lesions, 39% psoriasiform ones and 16% both. RESULTS: Lesions were mainly 
      localized on the neck and face and relapsed in spring and autumn. Seventeen 
      patients had 4 or more American College of Rheumatology criteria and could be 
      classified as having systemic lupus erythematosus. The most frequent 
      histopathological alterations were epidermal atrophy, hydropic degeneration of 
      the basal layer and perivascular lymphocytic infiltrate. Deposits of 
      immunoglobulins and C3 at the dermo-epidermal junction on the clinically involved 
      skin were present in 86% of the patients. Dust-like particles in the epidermis 
      were only found in 3% of cases. Anti-Ro/SSA antibodies were found in 71% of the 
      cases and anti-dsDNA only in 5% of cases. CONCLUSIONS: SCLE is a particular 
      subset of cutaneous lupus erythematosus with peculiar clinical and 
      immunopathological features.
CI  - Copyright (R) 2000 S. Karger AG, Basel
FAU - Parodi, A
AU  - Parodi A
AD  - Sezione di Dermatologia, Universita di Genova, DISEM, Genova, Italia.
FAU - Caproni, M
AU  - Caproni M
FAU - Cardinali, C
AU  - Cardinali C
FAU - Bernacchi, E
AU  - Bernacchi E
FAU - Fuligni, A
AU  - Fuligni A
FAU - De Panfilis, G
AU  - De Panfilis G
FAU - Zane, C
AU  - Zane C
FAU - Papini, M
AU  - Papini M
FAU - Veller, F C
AU  - Veller FC
FAU - Vaccaro, M
AU  - Vaccaro M
FAU - Fabbri, P
AU  - Fabbri P
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antinuclear/analysis
MH  - Child
MH  - Child, Preschool
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - Complement Hemolytic Activity Assay
MH  - Female
MH  - Fluorescent Antibody Technique, Direct
MH  - Humans
MH  - Immunoglobulins/analysis
MH  - Immunohistochemistry
MH  - Infant
MH  - Italy
MH  - Lupus Erythematosus, Cutaneous/immunology/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Skin/chemistry/immunology/*pathology
EDAT- 2000/02/22 09:00
MHDA- 2000/04/15 09:00
CRDT- 2000/02/22 09:00
PHST- 2000/02/22 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 2000/02/22 09:00 [entrez]
AID - 18307 [pii]
AID - 10.1159/000018307 [doi]
PST - ppublish
SO  - Dermatology. 2000;200(1):6-10. doi: 10.1159/000018307.