PMID- 10681821
OWN - NLM
STAT- MEDLINE
DCOM- 20000425
LR  - 20061115
IS  - 1000-5625 (Print)
IS  - 1000-5625 (Linking)
VI  - 23
IP  - 2
DP  - 1998
TI  - [The effect of brain-derived neurotrophic factor on the rat electroretinography 
      after pressure-induced ischemic injury].
PG  - 123-5
AB  - Brain-derived neurotrophic factor (BDNF) or normal goat serum (NGS) was injected 
      intravitreously in each 11 wistar albino rats two days before the induction of 
      ischemia. Retinal ischemia was induced in 22 rats by increasing intraocular 
      pressure to the threshold level which extinguished the electroretinography (ERG) 
      b-wave individually, and maintaining for 90 minutes. The ERG b-wave of the 
      BDNF-treated rats recovered to 80.5 +/- 24.4% of their normal amplitude three 
      days after ischemia, while that of the NGS-treated rats recovered only to 11.1 
      +/- 5.3%. Statistic analysis showed that the recovery level of ERG b-wave after 
      ischemia in the BDNF and NGS treated rats was significantly different (P < 0.01). 
      The results suggest that BDNF could promote the recovery of the retinal 
      electrophysiologic function from ischemia induced by high intraocular pressure.
FAU - Liu, Q
AU  - Liu Q
AD  - Department of Neurobiology, Hunan Medical University, Changha.
FAU - Pan, A
AU  - Pan A
FAU - Wen, X
AU  - Wen X
FAU - Luo, X
AU  - Luo X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Hunan Yi Ke Da Xue Xue Bao
JT  - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical 
      University
JID - 9424769
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Electroretinography
MH  - Female
MH  - Ischemia/etiology/*physiopathology
MH  - Male
MH  - Ocular Hypertension/chemically induced
MH  - Rats
MH  - Rats, Wistar
MH  - *Retinal Vessels
EDAT- 2000/02/22 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/02/22 09:00
PHST- 2000/02/22 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/02/22 09:00 [entrez]
PST - ppublish
SO  - Hunan Yi Ke Da Xue Xue Bao. 1998;23(2):123-5.