PMID- 10682593
OWN - NLM
STAT- MEDLINE
DCOM- 20000420
LR  - 20121115
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 27
IP  - 4
DP  - 1998 Jul
TI  - [Relation between methylmercury chloride-induced programmed cell death and the 
      development of nervous system in rats].
PG  - 241-4
AB  - The study was designed to reveal the role of programmed cell death (PCD, or 
      apoptosis) induced by methylmercury chloride (MMC) in SD rat embryos, wish 
      TdT-mediated dUTP nick end labeling (TUNEL), Nile blue sulfate (NBS) vital 
      stailing electron microscopy (SEM) and in vivo teratogenic methods (TEM). 
      Pregnant rats were intraperitoneally injected at gestation day 9.5 with doses of 
      0, 0.2, 0.4, 0.8, 1.6 and 3.2 mg/kg MMC and killed at 11.5 day later. Results 
      showed that the PCD of embryonic nervous system was apparently dose dependent 
      with MMC during rat head-fold stage. Observations under SEM and TEM showed that 
      MMC caused pathologic changes of epithelia and organellae in embryonic brain such 
      as atrophied or decreased microvilli cavernous damages and mitochondrial swelling 
      and so on. Though MMC could result in developmental anomalies of embryonic brain 
      and other organs, the main defect was open neural tube. The experiment study 
      suggested that over PCD may be one of the teratogenic mechanisms of MMC on rat 
      embryos, developing brain in particular.
FAU - Li, Y
AU  - Li Y
AD  - National Center for Maternal and Infant Health, Beijing Medical University, 
      China.
FAU - Pan, Y
AU  - Pan Y
FAU - Zhu, H
AU  - Zhu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Methylmercury Compounds)
RN  - RWZ4L3O1X0 (methylmercuric chloride)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Brain/embryology
MH  - Female
MH  - Male
MH  - Methylmercury Compounds/*adverse effects
MH  - Neural Tube Defects/*chemically induced
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/02/22 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/02/22 09:00
PHST- 2000/02/22 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/02/22 09:00 [entrez]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 1998 Jul;27(4):241-4.