PMID- 10682610
OWN - NLM
STAT- MEDLINE
DCOM- 20000324
LR  - 20211203
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 27
IP  - 2
DP  - 1998 Mar
TI  - [Observation of inducing effect of five kinds of soft wood dust in micronucleus 
      test].
PG  - 81-3
AB  - The authors investigated the micronucleus frequencies (MP) in peripheral 
      lymphocytes in 584 workers exposed to five kinds of soft wood dust and found that 
      all kinds of soft wood dust could increase the micronucleus frequency. As the 
      control's 95% confidential upper limit > or = 0.4% is defined as the standard for 
      positivity the micronucleus positive frequency (MPF) in the exposure group is 
      much higher than that in the control group (P < 0.01). Meanwhile the increase of 
      exposure years may increase the MP, and the time-response relationship is evident 
      (r = 0.90, P < 0.01). For different exposures, the MPFs are: 36.2% for linden, 
      26.3% for fir. 15.7% for lacebark pine, 9.6% for birch and 2.1% for polar. The 
      positive rate of linden and fir exposure are significantly higher than that of 
      the control group (P < 0.01). Water extract of these five kinds of soft wood dust 
      can increase the frequencies of micronucleus in polychromatic red blood cell in 
      mice's sternum marrow, which also showed a dose-response. The correlation 
      coefficients are: 0.86 for linden 0.6 for fir, 0.39 for lacebark pine, 0.76 for 
      birch and 0.73 for polar. All but the lacebark pine have the P value less than 
      0.01 (P < 0.01). At the dose of 15 g/kg body weight, micronucleus frequency 
      induced by linden was the highest (0.8%), next were fir (0.71%), birch (0.65%), 
      lacebark pine (0.63%), and polar (0.43%). The results from animal test are 
      consistent with those from the exposure workers. These results suggest that there 
      are some substances in soft wood which can induce chromosome aberration.
FAU - Jiang, Z
AU  - Jiang Z
AD  - Department of Occupational Health, Capital University of Medical Sciences, 
      Beijing, China.
FAU - Su, Y
AU  - Su Y
FAU - Wu, P
AU  - Wu P
FAU - Li, C
AU  - Li C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Dust)
RN  - 0 (Msln protein, mouse)
RN  - J27WDC343N (Mesothelin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Dust/*adverse effects
MH  - Female
MH  - Humans
MH  - Lymphocytes/pathology
MH  - Male
MH  - Mesothelin
MH  - Mice
MH  - Micronucleus Tests
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - *Wood
EDAT- 2000/02/22 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/02/22 09:00
PHST- 2000/02/22 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/22 09:00 [entrez]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 1998 Mar;27(2):81-3.