PMID- 10682977
OWN - NLM
STAT- MEDLINE
DCOM- 20000223
LR  - 20220309
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 129
IP  - 2
DP  - 2000 Feb
TI  - The human leukocyte antigen complex and chronic ocular inflammatory disorders.
PG  - 235-43
AB  - PURPOSE: To review the role of gene products from the human leukocyte antigen 
      (HLA) complex in the normal functioning of the immune system, ocular 
      inflammation, and models of autoimmunity. METHOD: A review of recently published 
      reports. RESULTS: Many chronic ocular inflammatory diseases are associated with 
      specific alleles of the HLA complex. Understanding how HLA gene products function 
      normally provides clues to the mechanism of disease associations. In the thymus, 
      these molecules control the shape of the developing T-cell repertoire, leading to 
      self-tolerance. In the periphery, HLA molecules bind and present peptide 
      fragments to T cells, leading to a variety of effector functions. Although 
      effector functions are for the most part beneficial, models are reviewed in which 
      peptide-HLA interactions lead to T-cell responses with pathologic consequences. 
      Herpes stromal keratitis is an informative animal model highlighting the role of 
      self-tolerance, infection, and molecular mimicry in the development of 
      autoimmunity. CONCLUSIONS: Human leukocyte antigen gene products may be 
      associated with chronic inflammatory disorders through the unique presentation of 
      "disease-inducing" peptides or the development of a T-cell repertoire prone to 
      autoreactivity and molecular mimicry.
FAU - Davey, M P
AU  - Davey MP
AD  - Department of Veteran Affairs Medical Center, Department of Medicine, Oregon 
      Health Sciences University, Portland 97201, USA. daveym@ohsu.edu
FAU - Rosenbaum, J T
AU  - Rosenbaum JT
LA  - eng
GR  - EY06477/EY/NEI NIH HHS/United States
GR  - EY06484/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity/*immunology
MH  - Chronic Disease
MH  - Genes, MHC Class I/physiology
MH  - Genes, MHC Class II/physiology
MH  - HLA Antigens/*physiology
MH  - Humans
MH  - Immune System/physiology
MH  - Keratitis, Herpetic/*immunology
MH  - T-Lymphocytes/immunology
MH  - Uveitis/*immunology
RF  - 56
EDAT- 2000/02/22 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/02/22 09:00
PHST- 2000/02/22 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/02/22 09:00 [entrez]
AID - S000293949900433X [pii]
AID - 10.1016/s0002-9394(99)00433-x [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2000 Feb;129(2):235-43. doi: 10.1016/s0002-9394(99)00433-x.